Development and functional diversification of cortical interneurons

L Lim, D Mi, A Llorca, O Marín - Neuron, 2018 - cell.com
In the cerebral cortex, GABAergic interneurons have evolved as a highly heterogeneous
collection of cell types that are characterized by their unique spatial and temporal …

New insights into the development of the human cerebral cortex

Z Molnár, GJ Clowry, N Šestan, A Alzu'bi… - Journal of …, 2019 - Wiley Online Library
The cerebral cortex constitutes more than half the volume of the human brain and is
presumed to be responsible for the neuronal computations underlying complex phenomena …

[HTML][HTML] Human prefrontal cortex gene regulatory dynamics from gestation to adulthood at single-cell resolution

CA Herring, RK Simmons, S Freytag, D Poppe… - Cell, 2022 - cell.com
Human brain development is underpinned by cellular and molecular reconfigurations
continuing into the third decade of life. To reveal cell dynamics orchestrating neural …

Human 3D cellular model of hypoxic brain injury of prematurity

AM Pașca, JY Park, HW Shin, Q Qi, O Revah… - Nature medicine, 2019 - nature.com
Owing to recent medical and technological advances in neonatal care, infants born
extremely premature have increased survival rates,. After birth, these infants are at high risk …

Cortical malformations: lessons in human brain development

L Subramanian, ME Calcagnotto… - Frontiers in cellular …, 2020 - frontiersin.org
Creating a functional cerebral cortex requires a series of complex and well-coordinated
developmental steps. These steps have evolved across species with the emergence of …

Human cerebral organoids—a new tool for clinical neurology research

OL Eichmüller, JA Knoblich - Nature Reviews Neurology, 2022 - nature.com
The current understanding of neurological diseases is derived mostly from direct analysis of
patients and from animal models of disease. However, most patient studies do not capture …

Therapeutic plasticity of neural stem cells

L Ottoboni, B von Wunster, G Martino - Frontiers in neurology, 2020 - frontiersin.org
Neural stem cells (NSCs) have garnered significant scientific and commercial interest in the
last 15 years. Given their plasticity, defined as the ability to develop into different phenotypes …

Cell-type-resolved mosaicism reveals clonal dynamics of the human forebrain

C Chung, X Yang, RF Hevner, K Kennedy, KI Vong… - Nature, 2024 - nature.com
Debate remains around the anatomical origins of specific brain cell subtypes and lineage
relationships within the human forebrain,,,,,–. Thus, direct observation in the mature human …

Brain size and limits to adult neurogenesis

MF Paredes, SF Sorrells… - Journal of …, 2016 - Wiley Online Library
The walls of the cerebral ventricles in the develo** embryo harbor the primary neural stem
cells from which most neurons and glia derive. In many vertebrates, neurogenesis continues …

[HTML][HTML] Human models are needed for studying human neurodevelopmental disorders

X Zhao, A Bhattacharyya - The American Journal of Human Genetics, 2018 - cell.com
The analysis of animal models of neurological disease has been instrumental in furthering
our understanding of neurodevelopment and brain diseases. However, animal models are …