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[HTML][HTML] Mechanisms of epigenetic regulation by C. elegans nuclear RNA interference pathways
RNA interference (RNAi) is a highly conserved gene regulatory phenomenon whereby
Argonaute/small RNA (AGO/sRNA) complexes target transcripts by antisense …
Argonaute/small RNA (AGO/sRNA) complexes target transcripts by antisense …
Inheritance and maintenance of small RNA‐mediated epigenetic effects
Heritable traits are predominantly encoded within genomic DNA, but it is now appreciated
that epigenetic information is also inherited through DNA methylation, histone modifications …
that epigenetic information is also inherited through DNA methylation, histone modifications …
Arabidopsis HOT3/eIF5B1 constrains rRNA RNAi by facilitating 18S rRNA maturation
R Hang, Y Xu, X Wang, H Hu, N Flynn, C You… - Proceedings of the …, 2023 - pnas.org
Ribosome biogenesis is essential for protein synthesis in gene expression. Yeast eIF5B has
been shown biochemically to facilitate 18S ribosomal RNA (rRNA) 3′ end maturation …
been shown biochemically to facilitate 18S ribosomal RNA (rRNA) 3′ end maturation …
Collagen and actin network mediate antiviral immunity against Orsay virus in C. elegans intestinal cells
Y Zhou, H Chen, W Zhong, YJ Tao - PLoS Pathogens, 2024 - journals.plos.org
C. elegans is a free-living nematode that is widely used as a small animal model for studying
fundamental biological processes and disease mechanisms. Since the discovery of the …
fundamental biological processes and disease mechanisms. Since the discovery of the …
Antisense ribosomal siRNAs inhibit RNA polymerase I-directed transcription in C. elegans
S Liao, X Chen, T Xu, Q **, Z Xu, D Xu… - Nucleic Acids …, 2021 - academic.oup.com
Eukaryotic cells express a wide variety of endogenous small regulatory RNAs that function
in the nucleus. We previously found that erroneous rRNAs induce the generation of …
in the nucleus. We previously found that erroneous rRNAs induce the generation of …
Non-coding RNA-driven regulation of rRNA biogenesis
Ribosomal RNA (rRNA) biogenesis takes place in the nucleolus, the most prominent
condensate of the eukaryotic nucleus. The proper assembly and integrity of the nucleolus …
condensate of the eukaryotic nucleus. The proper assembly and integrity of the nucleolus …
Poly(U) polymerase activity in Caenorhabditis elegans regulates abundance and tailing of sRNA and mRNA
Terminal nucleotidyltransferases add nucleotides to the 3′ end of RNA to modify their
stability and function. In Caenorhabditis elegans, the terminal uridyltransferases/poly (U) …
stability and function. In Caenorhabditis elegans, the terminal uridyltransferases/poly (U) …
Target-dependent suppression of siRNA production modulates the levels of endogenous siRNAs in the Caenorhabditis elegans germline
Z Gajic, D Kaur, J Ni, Z Zhu, A Zhebrun… - …, 2022 - journals.biologists.com
Despite the prominent role of endo-siRNAs in transposon silencing, their expression is not
limited to these 'nonself'DNA elements. Transcripts of protein-coding genes ('self'DNA) in …
limited to these 'nonself'DNA elements. Transcripts of protein-coding genes ('self'DNA) in …
Two germ granule eIF4E isoforms reside in different mRNPs to hand off C elegans mRNAs from translational repression to activation
G Gajjar, HP Huggins, ES Kim, W Huang, FX Bonnet… - …, 2024 - pmc.ncbi.nlm.nih.gov
We studied the function of translation factor eIF4E isoforms in regulating mRNAs in germ cell
granules/condensates. Translational control of mRNAs plays an essential role in germ cell …
granules/condensates. Translational control of mRNAs plays an essential role in germ cell …
Distinct regulatory mechanisms by the nuclear Argonautes HRDE-1 and NRDE-3 in the soma of Caenorhabditis elegans
ABSTRACT RNA interference is a conserved silencing mechanism that depends on the
generation of small RNA molecules that disrupt synthesis of their corresponding transcripts …
generation of small RNA molecules that disrupt synthesis of their corresponding transcripts …