[HTML][HTML] Mechanisms of epigenetic regulation by C. elegans nuclear RNA interference pathways

U Seroussi, C Li, AE Sundby, TL Lee… - Seminars in Cell & …, 2022 - Elsevier
RNA interference (RNAi) is a highly conserved gene regulatory phenomenon whereby
Argonaute/small RNA (AGO/sRNA) complexes target transcripts by antisense …

Inheritance and maintenance of small RNA‐mediated epigenetic effects

P Quarato, M Singh, L Bourdon, G Cecere - BioEssays, 2022 - Wiley Online Library
Heritable traits are predominantly encoded within genomic DNA, but it is now appreciated
that epigenetic information is also inherited through DNA methylation, histone modifications …

Arabidopsis HOT3/eIF5B1 constrains rRNA RNAi by facilitating 18S rRNA maturation

R Hang, Y Xu, X Wang, H Hu, N Flynn, C You… - Proceedings of the …, 2023 - pnas.org
Ribosome biogenesis is essential for protein synthesis in gene expression. Yeast eIF5B has
been shown biochemically to facilitate 18S ribosomal RNA (rRNA) 3′ end maturation …

Collagen and actin network mediate antiviral immunity against Orsay virus in C. elegans intestinal cells

Y Zhou, H Chen, W Zhong, YJ Tao - PLoS Pathogens, 2024 - journals.plos.org
C. elegans is a free-living nematode that is widely used as a small animal model for studying
fundamental biological processes and disease mechanisms. Since the discovery of the …

Antisense ribosomal siRNAs inhibit RNA polymerase I-directed transcription in C. elegans

S Liao, X Chen, T Xu, Q **, Z Xu, D Xu… - Nucleic Acids …, 2021 - academic.oup.com
Eukaryotic cells express a wide variety of endogenous small regulatory RNAs that function
in the nucleus. We previously found that erroneous rRNAs induce the generation of …

Non-coding RNA-driven regulation of rRNA biogenesis

EG Kaliatsi, N Giarimoglou, C Stathopoulos… - International journal of …, 2020 - mdpi.com
Ribosomal RNA (rRNA) biogenesis takes place in the nucleolus, the most prominent
condensate of the eukaryotic nucleus. The proper assembly and integrity of the nucleolus …

Poly(U) polymerase activity in Caenorhabditis elegans regulates abundance and tailing of sRNA and mRNA

LH Kelley, IV Caldas, MT Sullenberger, KE Yongblah… - Genetics, 2024 - academic.oup.com
Terminal nucleotidyltransferases add nucleotides to the 3′ end of RNA to modify their
stability and function. In Caenorhabditis elegans, the terminal uridyltransferases/poly (U) …

Target-dependent suppression of siRNA production modulates the levels of endogenous siRNAs in the Caenorhabditis elegans germline

Z Gajic, D Kaur, J Ni, Z Zhu, A Zhebrun… - …, 2022 - journals.biologists.com
Despite the prominent role of endo-siRNAs in transposon silencing, their expression is not
limited to these 'nonself'DNA elements. Transcripts of protein-coding genes ('self'DNA) in …

Two germ granule eIF4E isoforms reside in different mRNPs to hand off C elegans mRNAs from translational repression to activation

G Gajjar, HP Huggins, ES Kim, W Huang, FX Bonnet… - …, 2024 - pmc.ncbi.nlm.nih.gov
We studied the function of translation factor eIF4E isoforms in regulating mRNAs in germ cell
granules/condensates. Translational control of mRNAs plays an essential role in germ cell …

Distinct regulatory mechanisms by the nuclear Argonautes HRDE-1 and NRDE-3 in the soma of Caenorhabditis elegans

H Mendoza, E Jash, MB Davis, RA Haines… - bioRxiv, 2024 - biorxiv.org
ABSTRACT RNA interference is a conserved silencing mechanism that depends on the
generation of small RNA molecules that disrupt synthesis of their corresponding transcripts …