Clinical relevance of epigenetics in the onset and management of type 2 diabetes mellitus

L Sommese, A Zullo, FP Mancini, R Fabbricini… - Epigenetics, 2017 - Taylor & Francis
Epigenetics is involved in the altered expression of gene networks that underlie insulin
resistance and insufficiency. Major genes controlling β-cell differentiation and function, such …

Epigenetic control of β-cell function and failure

D Bernstein, ML Golson, KH Kaestner - Diabetes research and clinical …, 2017 - Elsevier
Type 2 diabetes is a highly heritable disease, but only∼ 15% of this heritability can be
explained by known genetic variant loci. In fact, body mass index is more predictive of …

Histone deacetylase inhibitors as antidiabetic agents: Advances and opportunities

M Sonthalia, BS Roy, D Chandrawanshi… - European Journal of …, 2022 - Elsevier
The loss of function or dysfunction of β-cells in the pancreas, attributed to the development of
diabetes, involve alterations in genetic and epigenetic signatures. Recent evidences …

Epigenetics and common non communicable disease

MA Tabatabaiefar, RS Sajjadi, S Narrei - Primordial Prevention of Non …, 2019 - Springer
Abstract Common Non communicable diseases (NCDs), such as cardiovascular disease,
cancer, schizophrenia, and diabetes, have become the major cause of death in the world …

HDACs in diabetes: A new era of epigenetic drug

LF Schütz, MH Park, M Choudhury - Nutritional and Therapeutic …, 2018 - Elsevier
Epigenetics, heritable modifications of gene expression, have been drawing the attention of
researchers for their potential implication in several diseases, including metabolic disorders …

Biological dogmas in relation to the origin of evolutionary novelties

P Tatemoto, C Guerrero-Bosagna - Origin and evolution of biodiversity, 2018 - Springer
Current evolutionary knowledge emerges influenced by two main currents of thinking. While
some call for more variables to be considered in evolution, others consider that evolutionary …