Lassa virus (LASV) is endemic in the rodent populations of Sierra Leone, Nigeria and other
countries in West Africa. Spillover to humans occurs frequently and results in Lassa fever, a …

Emerging viruses have the potential to impose substantial mortality, morbidity and economic
burdens on human populations. Tracking the spread of infectious diseases to assist in their …

Background The burden and influence of health-care associated severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2) infections is unknown. We aimed to examine the …

The CRISPR effector Cas13 could be an effective antiviral for single-stranded RNA (ssRNA)
viruses because it programmably cleaves RNAs complementary to its CRISPR RNA …

Genome sequencing has become a powerful tool for studying emerging infectious diseases;
however, genome sequencing directly from clinical samples (ie, without isolation and …

The magnitude of the COVID-19 pandemic underscores the urgency for a safe and effective
vaccine. Many vaccine candidates focus on the Spike protein, as it is targeted by …

Abstract Model-based molecular phylogenetics plays an important role in comparisons of
genomic data, and model selection is a key step in all such analyses. We present …

The 2018 Nigerian Lassa fever season saw the largest ever recorded upsurge of cases,
raising concerns over the emergence of a strain with increased transmission rate. To …

The 2013–2016 epidemic of Ebola virus disease in West Africa was of unprecedented
magnitude and changed our perspective on this lethal but sporadically emerging virus. This …

Recent outbreaks of viral hemorrhagic fevers (VHFs), including Ebola virus disease (EVD)
and Lassa fever (LF), highlight the urgent need for sensitive, deployable tests to diagnose …