The pleiotropic functions of reactive oxygen species in cancer

K Wu, AE El Zowalaty, VI Sayin… - Nature Cancer, 2024 - nature.com
Cellular redox homeostasis is an essential, dynamic process that ensures the balance
between reducing and oxidizing reactions within cells and thus has implications across all …

The role of ROS in tumour development and progression

EC Cheung, KH Vousden - Nature Reviews Cancer, 2022 - nature.com
Eukaryotic cells have developed complex systems to regulate the production and response
to reactive oxygen species (ROS). Different ROS control diverse aspects of cell behaviour …

Cancer metabolism: looking forward

I Martínez-Reyes, NS Chandel - Nature Reviews Cancer, 2021 - nature.com
Tumour initiation and progression requires the metabolic reprogramming of cancer cells.
Cancer cells autonomously alter their flux through various metabolic pathways in order to …

Matrix metalloproteinases shape the tumor microenvironment in cancer progression

S Niland, AX Riscanevo, JA Eble - International journal of molecular …, 2021 - mdpi.com
Cancer progression with uncontrolled tumor growth, local invasion, and metastasis depends
largely on the proteolytic activity of numerous matrix metalloproteinases (MMPs), which …

[HTML][HTML] Oxidative stress in cancer

JD Hayes, AT Dinkova-Kostova, KD Tew - Cancer cell, 2020 - cell.com
Contingent upon concentration, reactive oxygen species (ROS) influence cancer evolution
in apparently contradictory ways, either initiating/stimulating tumorigenesis and supporting …

Antioxidant peptides, the guardian of life from oxidative stress

Y Zhu, K Wang, X Jia, C Fu, H Yu… - Medicinal Research …, 2024 - Wiley Online Library
Reactive oxygen species (ROS) are produced during oxidative metabolism in aerobic
organisms. Under normal conditions, ROS production and elimination are in a relatively …

ROS in cancer therapy: the bright side of the moon

B Perillo, M Di Donato, A Pezone, E Di Zazzo… - … & molecular medicine, 2020 - nature.com
Reactive oxygen species (ROS) constitute a group of highly reactive molecules that have
evolved as regulators of important signaling pathways. It is now well accepted that moderate …

The complex interplay between antioxidants and ROS in cancer

IS Harris, GM DeNicola - Trends in cell biology, 2020 - cell.com
Reactive oxygen species (ROS) play important roles in tissue homeostasis, cellular
signaling, differentiation, and survival. In this review, we discuss the types of ROS, their …

Extracellular matrix in the tumor microenvironment and its impact on cancer therapy

E Henke, R Nandigama, S Ergün - Frontiers in molecular biosciences, 2020 - frontiersin.org
Solid tumors are complex organ-like structures that consist not only of tumor cells but also of
vasculature, extracellular matrix (ECM), stromal, and immune cells. Often, this tumor …

ROS and diseases: Role in metabolism and energy supply

S Yang, G Lian - Molecular and cellular biochemistry, 2020 - Springer
Researches dedicated to reactive oxygen species (ROS) had been performed for decades,
yet the outcomes remain controversial. With the relentless effort of studies, researchers have …