Microglia are the resident macrophages of the central nervous system. Microglia possess
varied morphologies and functions. Under normal physiological conditions, microglia mainly …

The recent outbreak of the corona virus disease (COVID-19) has had major global impact.
The relationship between severe acute respiratory syndrome coronavirus (SARS-CoV-2) …

Synapse remodeling is essential to encode experiences into neuronal circuits. Here, we
define a molecular interaction between neurons and microglia that drives experience …

Astrocytic contributions to neuroinflammation are widely implicated in disease, but they
remain incompletely explored. We assess medial prefrontal cortex (PFC) and visual cortex …

Immune dysregulated cytokine production is involved in mental diseases. However, the
results are inconsistent and the pattern of cytokine alterations has not been compared …

Alzheimer's disease (AD) is a neurodegenerative disorder characterized by protein
aggregation in the brain. Recent studies have revealed the critical role of microglia in AD …

Mast cells (MCs) are evolutionarily ancient innate immune cells with important roles in
protective immunity against bacteria, parasites, and venomous animals. They can be found …

Microglia are critical regulators of brain development that engulf synaptic proteins during
postnatal synapse remodeling. However, the mechanisms through which microglia sense …

Bipolar disorder (BD) is a neuropsychiatric mood disorder manifested by recurrent episodes
of mania and depression. More than half of BD patients are non-responsive to lithium, the …

Posttraumatic stress disorder (PTSD) imposes a significant burden on patients and
communities. Although the microbiome-gut-brain axis has been proposed as a mediator or …