Lung cancer epigenetics: from knowledge to applications

M Duruisseaux, M Esteller - Seminars in cancer biology, 2018 - Elsevier
Lung cancer is the leading cause of cancer-related mortality worldwide. Advances in our
understanding of the genomics of lung cancer have led to substantial progress in the …

LncRNA in tumorigenesis of non-small-cell lung cancer: From bench to bedside

Q Hu, H Ma, H Chen, Z Zhang, Q Xue - Cell death discovery, 2022 - nature.com
Lung cancer has been one of the leading causes of cancer-related death worldwide, and
non-small-cell lung cancer (NSCLC) accounts for the majority of lung cancer morbidity, yet …

A novel long noncoding RNA HOXC-AS3 mediates tumorigenesis of gastric cancer by binding to YBX1

E Zhang, X He, C Zhang, J Su, X Lu, X Si, J Chen… - Genome biology, 2018 - Springer
Background Recently, increasing evidence shows that long noncoding RNAs (lncRNAs)
play a significant role in human tumorigenesis. However, the function of lncRNAs in human …

Exosome-transmitted lncRNA UFC1 promotes non-small-cell lung cancer progression by EZH2-mediated epigenetic silencing of PTEN expression

X Zang, J Gu, J Zhang, H Shi, S Hou, X Xu… - Cell death & …, 2020 - nature.com
Abstract Long non-coding RNAs (LncRNAs) have been suggested as important regulators of
cancer development and progression in non-small cell lung cancer (NSCLC). Nevertheless …

FOXC1-mediated LINC00301 facilitates tumor progression and triggers an immune-suppressing microenvironment in non-small cell lung cancer by regulating the …

CC Sun, W Zhu, SJ Li, W Hu, J Zhang, Y Zhuo… - Genome medicine, 2020 - Springer
Abstract Background Long non-coding RNAs (lncRNAs) are extensively intricate in the
tumorigenesis and metastasis of various cancer types. Nevertheless, the detailed molecular …

CREB stimulates GPX4 transcription to inhibit ferroptosis in lung adenocarcinoma

Z Wang, X Zhang, X Tian, Y Yang, L Ma… - Oncology …, 2021 - spandidos-publications.com
Ferroptosis is a new form of regulated cell death and closely related to cancer. However, the
mechanism underlying the regulation of ferroptosis in lung adenocarcinoma (LUAD) …

[HTML][HTML] Sex-specific role for the long non-coding RNA LINC00473 in depression

O Issler, YY van der Zee, A Ramakrishnan, J Wang… - Neuron, 2020 - cell.com
Depression is a common disorder that affects women at twice the rate of men. Here, we
report that long non-coding RNAs (lncRNAs), a recently discovered class of regulatory …

[HTML][HTML] CircACC1 regulates assembly and activation of AMPK complex under metabolic stress

Q Li, Y Wang, S Wu, Z Zhou, X Ding, R Shi, RF Thorne… - Cell metabolism, 2019 - cell.com
We report that circACC1, a circular RNA derived from human ACC1, plays a critical role in
cellular responses to metabolic stress. CircACC1 is preferentially produced over ACC1 in …

Long noncoding RNA XIST acts as an oncogene in non-small cell lung cancer by epigenetically repressing KLF2 expression

J Fang, CC Sun, C Gong - Biochemical and biophysical research …, 2016 - Elsevier
Recently, long noncoding RNAs (lncRNAs) have been identified as critical regulators in
numerous types of cancers, including non-small cell lung cancer (NSCLC). X inactivate …

MetaLnc9 facilitates lung cancer metastasis via a PGK1-activated AKT/mTOR pathway

T Yu, Y Zhao, Z Hu, J Li, D Chu, J Zhang, Z Li… - Cancer …, 2017 - aacrjournals.org
Long noncoding RNAs (lncRNA) participate in carcinogenesis and tumor progression in
lung cancer. Here, we report the identification of a lncRNA signature associated with …