Signaling pathways involved in ischemic stroke: molecular mechanisms and therapeutic interventions

C Qin, S Yang, YH Chu, H Zhang, XW Pang… - Signal transduction and …, 2022 - nature.com
Ischemic stroke is caused primarily by an interruption in cerebral blood flow, which induces
severe neural injuries, and is one of the leading causes of death and disability worldwide …

[HTML][HTML] Phosphorylated tau in Alzheimer's disease and other tauopathies

P Rawat, U Sehar, J Bisht, A Selman… - International journal of …, 2022 - mdpi.com
Alzheimer's disease (AD) is the leading cause of dementia in elderly people. Amyloid beta
(Aβ) deposits and neurofibrillary tangles are the major pathological features in an …

ER stress and UPR in Alzheimer's disease: mechanisms, pathogenesis, treatments

A Ajoolabady, D Lindholm, J Ren, D Pratico - Cell death & disease, 2022 - nature.com
Alzheimer's disease (AD) is a devastating neurodegenerative disorder characterized by
gradual loss of memory and cognitive function, which constitutes a heavy burden on the …

Bidirectional relationship between sleep and Alzheimer's disease: role of amyloid, tau, and other factors

C Wang, DM Holtzman - Neuropsychopharmacology, 2020 - nature.com
As we age, we experience changes in our nighttime sleep and daytime wakefulness.
Individuals afflicted with Alzheimer's disease (AD) can develop sleep problems even before …

Role of tau protein in Alzheimer's disease: The prime pathological player

S Muralidar, SV Ambi, S Sekaran, D Thirumalai… - International journal of …, 2020 - Elsevier
Alzheimer's disease (AD) is a prevalently found tauopathy characterized by memory loss
and cognitive insufficiency. AD is an age-related neurodegenerative disease with two major …

[HTML][HTML] Impairment of the autophagy–lysosomal pathway in Alzheimer's diseases: pathogenic mechanisms and therapeutic potential

W Zhang, C Xu, J Sun, HM Shen, J Wang… - … Pharmaceutica Sinica B, 2022 - Elsevier
Abstract Alzheimer's disease (AD), the most common neurodegenerative disorder, is
characterized by memory loss and cognitive dysfunction. The accumulation of misfolded …

[HTML][HTML] Passive immunotherapy for Alzheimer's disease

X Guo, L Yan, D Zhang, Y Zhao - Ageing Research Reviews, 2024 - Elsevier
Alzheimer's disease (AD) is the most common neurodegenerative disease characterized by
cognitive impairment with few therapeutic options. Despite many failures in develo** AD …

Pharmacological attributes of Bacopa monnieri extract: Current updates and clinical manifestation

U Fatima, S Roy, S Ahmad, S Ali, WM Elkady… - Frontiers in …, 2022 - frontiersin.org
Bacopa monnieri has been used for centuries in Ayurvedic medicine, alone or in
combination with other herbs, as a memory and learning enhancer, sedative, and anti …

Curcumin and its derivatives: their application in neuropharmacology and neuroscience in the 21st century

WH Lee, CY Loo, M Bebawy, F Luk… - Current …, 2013 - ingentaconnect.com
Curcumin (diferuloylmethane), a polyphenol extracted from the plant Curcuma longa, is
widely used in Southeast Asia, China and India in food preparation and for medicinal …

Role of hydroxytyrosol and oleuropein in the prevention of aging and related disorders: focus on neurodegeneration, skeletal muscle dysfunction and gut microbiota

L Micheli, L Bertini, A Bonato, N Villanova, C Caruso… - Nutrients, 2023 - mdpi.com
Aging is a multi-faceted process caused by the accumulation of cellular damage over time,
associated with a gradual reduction of physiological activities in cells and organs. This …