An overview of the biological evaluation of selected nitrogen-containing heterocycle medicinal chemistry compounds
O Ebenezer, MA Jordaan, G Carena, T Bono… - International Journal of …, 2022 - mdpi.com
Heterocyclic compounds are a class of compounds of natural origin with favorable
properties and hence have major pharmaceutical significance. They have an exceptional …
properties and hence have major pharmaceutical significance. They have an exceptional …
An outlook of docking analysis and structure-activity relationship of pyrimidine-based analogues as EGFR inhibitors against non-small cell lung cancer (NSCLC)
Almost 80% of lung cancer diagnoses each year correspond to non-small cell lung cancer
(NSCLC). The percentage of NSCLC with EGFR overexpression ranges from 40% to 89 …
(NSCLC). The percentage of NSCLC with EGFR overexpression ranges from 40% to 89 …
Design and evaluation of sulfadiazine derivatives as potent dual inhibitors of EGFR WT and EGFR T790M: integrating biological, molecular docking, and ADMET …
A series of derivatives (5–14) were synthesized through the diazotization of sulfadiazine with
active methylene compounds. The chemical structures of these newly designed compounds …
active methylene compounds. The chemical structures of these newly designed compounds …
Designing strategies, structural activity relationship and biological activity of recently developed nitrogen containing heterocyclic compounds as epidermal growth …
Cancer cells have the ability of dysregulation and autonomous proliferation due to
unchecked production of definite molecules. These molecules are involved in the cell growth …
unchecked production of definite molecules. These molecules are involved in the cell growth …
Novel pyrazolo [3, 4-d] pyrimidine derivatives: design, synthesis, anticancer evaluation, VEGFR-2 inhibition, and antiangiogenic activity
AM Abdelhamed, RA Hassan, HH Kadry… - RSC Medicinal …, 2023 - pubs.rsc.org
A novel series of 12 pyrazolo [3, 4-d] pyrimidine derivatives were created and evaluated in
vitro for their antiproliferative activity against the NCI 60 human tumor cell line panel …
vitro for their antiproliferative activity against the NCI 60 human tumor cell line panel …
Pyrazolo[3,4‐d]pyrimidine scaffold: A review on synthetic approaches and EGFR and VEGFR inhibitory activities
AE Kassab - Archiv der Pharmazie, 2023 - Wiley Online Library
Abstract The pyrazolo [3, 4‐d] pyrimidine core has received a lot of interest from the
medicinal chemistry community as a promising framework for drug design and discovery. It …
medicinal chemistry community as a promising framework for drug design and discovery. It …
Pyrazole, Pyrazoline, and Fused Pyrazole Derivatives: New Horizons in EGFR‐Targeted Anticancer Agents
Pyrazole and its derivatives remain popular heterocycles in drug research, design, and
development. Several drugs include the pyrazole scaffold, such as ramifenazone …
development. Several drugs include the pyrazole scaffold, such as ramifenazone …
Nitrogen‐Containing Heterocyclic Scaffolds as EGFR Inhibitors: Design Approaches, Molecular Docking, and Structure‐Activity Relationships
Cancer is a wide collection of diseases and among the numerous pathways involved in
cancer pathogenesis, pathway involving epidermal growth factor receptor (EGFR) is one of …
cancer pathogenesis, pathway involving epidermal growth factor receptor (EGFR) is one of …
Design, synthesis, biological evaluation, in silico ADME prediction and molecular docking of pyrazole-benzamides as multitargeting protien kinase inhibitors
In the present study, N-(1-(2-bromobenzoyl)-4-cyano-1H-pyrazol-5-yl) halogenated
benzamides (5a-h) were prepared and evaluated for their in vitro anticancer activity against …
benzamides (5a-h) were prepared and evaluated for their in vitro anticancer activity against …
Novel Pyrimidine-5-Carbonitriles as potential apoptotic and antiproliferative agents by dual inhibition of EGFRWT/T790M and PI3k enzymes; Design, Synthesis …
Abstract A new series of 6-(4-fluorophenyl)-2-(methylthio) pyrimidine-5-carbonitrile
derivatives were designed and synthesized as EGFR/PI3K dual inhibitors, and potential …
derivatives were designed and synthesized as EGFR/PI3K dual inhibitors, and potential …