Novel strategies to improve tumour therapy by targeting the proteins MCT1, MCT4 and LAT1
Y Wang, L Qin, W Chen, Q Chen, J Sun… - European Journal of …, 2021 - Elsevier
Poor selectivity, potential systemic toxicity and drug resistance are the main challenges
associated with chemotherapeutic drugs. MCT1 and MCT4 and LAT1 play vital roles in …
associated with chemotherapeutic drugs. MCT1 and MCT4 and LAT1 play vital roles in …
SLC16 family: from atomic structure to human disease
PD Bosshart, RP Charles, RAA Garibsingh… - Trends in biochemical …, 2021 - cell.com
The solute carrier 16 (SLC16) family represents a diverse group of membrane proteins
mediating the transport of monocarboxylates across biological membranes. Family members …
mediating the transport of monocarboxylates across biological membranes. Family members …
The making of a potent L-lactate transport inhibitor
PD Bosshart, D Kalbermatter, S Bonetti… - Communications …, 2021 - nature.com
L-lactate is an important metabolite, energy source, and signaling molecule in health and
disease. In mammals, its transport across biological membranes is mediated by …
disease. In mammals, its transport across biological membranes is mediated by …
Comparative immunogenicity of outer membrane protein K and whole‐cell antigens of Vibrio parahaemolyticus for diagnosis
W Wang, S Guo, Y Gao, X Liang, L Liu… - Letters in Applied …, 2021 - academic.oup.com
The immunogenicity of soluble outer membrane protein K (OmpK)‐small ubiquitin‐like
modifier, OmpK inclusion bodies, formalin, and heat‐killed Vibrio parahaemolyticus cells …
modifier, OmpK inclusion bodies, formalin, and heat‐killed Vibrio parahaemolyticus cells …
Uncovering Novel Plasma Membrane Carboxylate Transporters in the Yeast Cyberlindnera jadinii
The yeast Cyberlindnera jadinii has great potential in the biotechnology industry due to its
ability to produce a variety of compounds of interest, including carboxylic acids. In this work …
ability to produce a variety of compounds of interest, including carboxylic acids. In this work …
Pichia pastoris and the Recombinant Human Heterodimeric Amino Acid Transporter 4F2hc-LAT1: From Clone Selection to Pure Protein
S Kantipudi, D Harder, S Bonetti, D Fotiadis… - Methods and …, 2021 - mdpi.com
Heterodimeric amino acid transporters (HATs) are protein complexes composed of two
subunits, a heavy and a light subunit belonging to the solute carrier (SLC) families SLC3 …
subunits, a heavy and a light subunit belonging to the solute carrier (SLC) families SLC3 …
A procedure and double-chambered device for macromolecular crystal flash-cooling in different cryogenic liquids
JM Jeckelmann, H Ilgü, PD Bosshart, D Fotiadis - PloS one, 2020 - journals.plos.org
Flash-cooling of macromolecular crystals for X-ray diffraction analysis is usually performed
in liquid nitrogen (LN2). Cryogens different than LN2 are used as well for this procedure but …
in liquid nitrogen (LN2). Cryogens different than LN2 are used as well for this procedure but …
Crystallization, X-ray diffraction analysis and structure of ICMP from Pseudomonas aeruginosa
J Wang, R Pi, G Lu - Biochemical and Biophysical Research …, 2022 - Elsevier
Insulin-cleaving membrane protease (ICMP), an outmember protein of Pseudomonas
aeruginosa (P. aeruginosa), plays a critical role in the pathogenesis of the bacterium. ICMP …
aeruginosa (P. aeruginosa), plays a critical role in the pathogenesis of the bacterium. ICMP …