The microbiome–gut–brain axis in Parkinson disease—from basic research to the clinic

AH Tan, SY Lim, AE Lang - Nature Reviews Neurology, 2022 - nature.com
Evidence for a close bidirectional link between the brain and the gut has led to a paradigm
shift in neurology, especially in the case of Parkinson disease (PD), in which gastrointestinal …

The role of the gut microbiota in the relationship between diet and human health

BK Perler, ES Friedman, GD Wu - Annual review of physiology, 2023 - annualreviews.org
The interplay between diet, the gut microbiome, and host health is complex. Diets
associated with health have many similarities: high fiber, unsaturated fatty acids, and …

The gut microbiota and inflammation: an overview

Z Al Bander, MD Nitert, A Mousa… - International journal of …, 2020 - mdpi.com
The gut microbiota encompasses a diverse community of bacteria that carry out various
functions influencing the overall health of the host. These comprise nutrient metabolism …

Emerging role of trimethylamine-N-oxide (TMAO) in colorectal cancer

R Jalandra, N Dalal, AK Yadav, D Verma… - Applied Microbiology …, 2021 - Springer
Among gut microbiota-derived metabolites, trimethylamine-N-oxide (TMAO) is receiving
increased attention due to its possible role in the carcinogenesis of colorectal cancer (CRC) …

Nutritional components in Western diet versus Mediterranean diet at the gut microbiota–immune system interplay. Implications for health and disease

C García-Montero, O Fraile-Martínez… - Nutrients, 2021 - mdpi.com
The most prevalent diseases of our time, non-communicable diseases (NCDs)(including
obesity, type 2 diabetes, cardiovascular diseases and some types of cancer) are rising …

Microbial-derived metabolites as a risk factor of age-related cognitive decline and dementia

E Connell, G Le Gall, MG Pontifex, S Sami… - Molecular …, 2022 - Springer
A consequence of our progressively ageing global population is the increasing prevalence
of worldwide age-related cognitive decline and dementia. In the absence of effective …

Gut microbiome-wide association study of depressive symptoms

D Radjabzadeh, JA Bosch, AG Uitterlinden… - Nature …, 2022 - nature.com
Depression is one of the most poorly understood diseases due to its elusive pathogenesis.
There is an urgency to identify molecular and biological mechanisms underlying depression …

Metabolomics for investigating physiological and pathophysiological processes

DS Wishart - Physiological reviews, 2019 - journals.physiology.org
Metabolomics uses advanced analytical chemistry techniques to enable the high-throughput
characterization of metabolites from cells, organs, tissues, or biofluids. The rapid growth in …

[HTML][HTML] The effects of vegetarian and vegan diets on gut microbiota

A Tomova, I Bukovsky, E Rembert, W Yonas… - Frontiers in …, 2019 - frontiersin.org
The difference in gut microbiota composition between individuals following vegan or
vegetarian diets and those following omnivorous diets is well documented. A plant-based …

[HTML][HTML] Trimethylamine N-oxide (TMAO) in human health

P Gatarek, J Kaluzna-Czaplinska - EXCLI journal, 2021 - ncbi.nlm.nih.gov
Due to numerous links between trimethylamine-N-oxide (TMAO) and various disorders and
diseases, this topic is very popular and is often taken up by researchers. TMAO is a low …