Hydrogels for RNA delivery
RNA-based therapeutics have shown tremendous promise in disease intervention at the
genetic level, and some have been approved for clinical use, including the recent COVID-19 …
genetic level, and some have been approved for clinical use, including the recent COVID-19 …
[HTML][HTML] Sustained delivery approaches to improving adaptive immune responses
The immune system is one of the most important, complex biological networks regulating
and protecting human health. Its precise modulation can prevent deadly infections and fight …
and protecting human health. Its precise modulation can prevent deadly infections and fight …
Accelerating the prediction and discovery of peptide hydrogels with human-in-the-loop
The amino acid sequences of peptides determine their self-assembling properties. Accurate
prediction of peptidic hydrogel formation, however, remains a challenging task. This work …
prediction of peptidic hydrogel formation, however, remains a challenging task. This work …
Recent advances in micro-and nano-scale carrier systems for controlled delivery of vaccines
Vaccines provide substantial safety against infectious diseases, saving millions of lives each
year. The recent COVID-19 pandemic highlighted the importance of vaccination in providing …
year. The recent COVID-19 pandemic highlighted the importance of vaccination in providing …
In vivo fate and intracellular trafficking of vaccine delivery systems
With the pandemic of severe acute respiratory syndrome coronavirus 2, vaccine delivery
systems emerged as a core technology for global public health. Given that antigen …
systems emerged as a core technology for global public health. Given that antigen …
Long-acting vaccine delivery systems
Bolus vaccines are often administered multiple times due to rapid clearance and reduced
transportation to draining lymph nodes resulting in inadequate activation of T and B …
transportation to draining lymph nodes resulting in inadequate activation of T and B …
Engineering multifunctional dynamic hydrogel for biomedical and tissue regenerative applications
Hydrogels have emerged in various biomedical applications, including tissue engineering
and medical devices, due to their ability to imitate the natural extracellular matrix (ECM) of …
and medical devices, due to their ability to imitate the natural extracellular matrix (ECM) of …
Polysaccharide-based hydrogels for drug delivery and wound management: a review
ABSTRACT Introduction Polysaccharide-based hydrogels (PBHs) offer several advantages
over their synthetic counterparts. Their natural origin contributes to their nontoxicity, high …
over their synthetic counterparts. Their natural origin contributes to their nontoxicity, high …
Two-dose priming immunization amplifies humoral immunity by synchronizing vaccine delivery with the germinal center response
Prolonging exposure to subunit vaccines during the primary immune response enhances
humoral immunity. Escalating-dose immunization (EDI), administering vaccines every other …
humoral immunity. Escalating-dose immunization (EDI), administering vaccines every other …
Tannic acid-based sustained-release system for protein drugs
K Utatsu, K Motoyama, T Nakamura, R Onodera… - International Journal of …, 2023 - Elsevier
In recent years, protein drug development has gained momentum, and simple and facile
controlled-release systems without loss of activity are required. Herein, we developed a …
controlled-release systems without loss of activity are required. Herein, we developed a …