RNA-based therapeutics have shown tremendous promise in disease intervention at the
genetic level, and some have been approved for clinical use, including the recent COVID-19 …

Hydrogels have emerged in various biomedical applications, including tissue engineering
and medical devices, due to their ability to imitate the natural extracellular matrix (ECM) of …

The amino acid sequences of peptides determine their self-assembling properties. Accurate
prediction of peptidic hydrogel formation, however, remains a challenging task. This work …

The immune system is one of the most important, complex biological networks regulating
and protecting human health. Its precise modulation can prevent deadly infections and fight …

Vaccines provide substantial safety against infectious diseases, saving millions of lives each
year. The recent COVID-19 pandemic highlighted the importance of vaccination in providing …

Prolonging exposure to subunit vaccines during the primary immune response enhances
humoral immunity. Escalating-dose immunization (EDI), administering vaccines every other …

With the pandemic of severe acute respiratory syndrome coronavirus 2, vaccine delivery
systems emerged as a core technology for global public health. Given that antigen …

ABSTRACT Introduction Polysaccharide-based hydrogels (PBHs) offer several advantages
over their synthetic counterparts. Their natural origin contributes to their nontoxicity, high …

Bolus vaccines are often administered multiple times due to rapid clearance and reduced
transportation to draining lymph nodes resulting in inadequate activation of T and B …

Poly (I: C) is a synthetic analogue of dsRNA capable of activating both TLR3 and RLRs,
such as MDA‐5 and RIG‐I, as pathogen recognition receptors. While poly (I: C) is known to …