Network pharmacology prediction and molecular docking-based strategy to explore the potential mechanism of Huanglian Jiedu Decoction against sepsis

X Li, S Wei, S Niu, X Ma, H Li, M **g, Y Zhao - Computers in biology and …, 2022 - Elsevier
Abstract Background Huanglian Jiedu Decoction (HLJDD) is a classical herbal formula with
potential efficacy in the treatment of sepsis. However, the main components and potential …

Review on natural products databases: where to find data in 2020

M Sorokina, C Steinbeck - Journal of cheminformatics, 2020 - Springer
Natural products (NPs) have been the centre of attention of the scientific community in the
last decencies and the interest around them continues to grow incessantly. As a …

[HTML][HTML] Elevated glucose levels favor SARS-CoV-2 infection and monocyte response through a HIF-1α/glycolysis-dependent axis

AC Codo, GG Davanzo, L de Brito Monteiro… - Cell metabolism, 2020 - cell.com
COVID-19 can result in severe lung injury. It remained to be determined why diabetic
individuals with uncontrolled glucose levels are more prone to develop the severe form of …

Gut microbiome and metabolome profiling in Framingham heart study reveals cholesterol-metabolizing bacteria

C Li, M Stražar, AMT Mohamed, JA Pacheco… - Cell, 2024 - cell.com
Accumulating evidence suggests that cardiovascular disease (CVD) is associated with an
altered gut microbiome. Our understanding of the underlying mechanisms has been …

[HTML][HTML] The DisGeNET cytoscape app: Exploring and visualizing disease genomics data

J Piñero, J Saüch, F Sanz, LI Furlong - Computational and structural …, 2021 - Elsevier
Thanks to the unbiased exploration of genomic variants at large scale, hundreds of
thousands of disease-associated loci have been uncovered. In parallel, network-based …

Mobile genetic elements from the maternal microbiome shape infant gut microbial assembly and metabolism

T Vatanen, KS Jabbar, T Ruohtula, J Honkanen… - Cell, 2022 - cell.com
The perinatal period represents a critical window for cognitive and immune system
development, promoted by maternal and infant gut microbiomes and their metabolites. Here …

State of the field in multi-omics research: from computational needs to data mining and sharing

M Krassowski, V Das, SK Sahu, BB Misra - Frontiers in Genetics, 2020 - frontiersin.org
Multi-omics, variously called integrated omics, pan-omics, and trans-omics, aims to combine
two or more omics data sets to aid in data analysis, visualization and interpretation to …

Structure and function of rice hybrid genomes reveal genetic basis and optimal performance of heterosis

Z Gu, J Gong, Z Zhu, Z Li, Q Feng, C Wang, Y Zhao… - Nature Genetics, 2023 - nature.com
Exploitation of crop heterosis is crucial for increasing global agriculture production.
However, the quantitative genomic analysis of heterosis was lacking, and there is currently …

Efficient analysis of toxicity and mechanisms of environmental pollutants with network toxicology and molecular docking strategy: Acetyl tributyl citrate as an example

S Huang - Science of The Total Environment, 2023 - Elsevier
The study aims to promote network toxicology strategy to efficiently investigate the putative
toxicity and underlying molecular mechanisms of environmental pollutants through an …

LncRNA RP11-89 facilitates tumorigenesis and ferroptosis resistance through PROM2-activated iron export by sponging miR-129-5p in bladder cancer

W Luo, J Wang, W Xu, C Ma, F Wan, Y Huang… - Cell death & …, 2021 - nature.com
Long non-coding RNAs (lncRNAs) act as important regulators of tumorigenesis and
development in bladder cancer. However, the underlying molecular mechanisms remain …