Proneural genes and the specification of neural cell types
Certain morphological, physiological and molecular characteristics are shared by all
neurons. However, despite these similarities, neurons constitute the most diverse cell …
neurons. However, despite these similarities, neurons constitute the most diverse cell …
The unfolded protein response and hepatic lipid metabolism in non alcoholic fatty liver disease
MJ Song, H Malhi - Pharmacology & therapeutics, 2019 - Elsevier
Nonalcoholic fatty liver disease is a major public health burden. Although many features of
nonalcoholic fatty liver disease pathogenesis are known, the specific mechanisms and …
nonalcoholic fatty liver disease pathogenesis are known, the specific mechanisms and …
ROS-Induced JNK and p38 Signaling Is Required for Unpaired Cytokine Activation during Drosophila Regeneration
P Santabarbara-Ruiz, M Lopez-Santillan… - PLoS …, 2015 - journals.plos.org
Upon apoptotic stimuli, epithelial cells compensate the gaps left by dead cells by activating
proliferation. This has led to the proposal that dying cells signal to surrounding living cells to …
proliferation. This has led to the proposal that dying cells signal to surrounding living cells to …
Pattern formation by lateral inhibition with feedback: a mathematical model of delta-notch intercellular signalling
In many develo** tissues, adjacent cells diverge in character so as to create a fine-
grained pattern of cells in contrasting states of differentiation. It has been proposed that such …
grained pattern of cells in contrasting states of differentiation. It has been proposed that such …
Chemical genetic discovery of targets and anti-targets for cancer polypharmacology
The complexity of cancer has led to recent interest in polypharmacological approaches for
develo** kinase-inhibitor drugs; however, optimal kinase-inhibition profiles remain difficult …
develo** kinase-inhibitor drugs; however, optimal kinase-inhibition profiles remain difficult …
Flamingo, a seven-pass transmembrane cadherin, regulates planar cell polarity under the control of Frizzled
T Usui, Y Shima, Y Shimada, S Hirano, RW Burgess… - Cell, 1999 - cell.com
We identified a seven-pass transmembrane receptor of the cadherin superfamily,
designated Flamingo (Fmi), localized at cell–cell boundaries in the Drosophila wing. In the …
designated Flamingo (Fmi), localized at cell–cell boundaries in the Drosophila wing. In the …
Expression of crumbs confers apical character on plasma membrane domains of ectodermal epithelia of Drosophila
The crumbs protein of Drosophila is an integral membrane protein, with 30 EGF-like and 4
lamlnin AG domain-like repeats in its extracellular segment, which is expressed on the …
lamlnin AG domain-like repeats in its extracellular segment, which is expressed on the …
Identification of neurogenin, a vertebrate neuronal determination gene
Several bHLH proteins are involved in vertebrate neurogenesis, but those controlling early
stages of neuronal determination have not yet been identified. Here we describe a novel …
stages of neuronal determination have not yet been identified. Here we describe a novel …
Expression of achaete-scute homolog 3 in Xenopus embryos converts ectodermal cells to a neural fate.
DL Turner, H Weintraub - Genes & development, 1994 - genesdev.cshlp.org
In Drosophila, the proneural genes of the achaete-scute complex encode transcriptional
activators that can commit cells to a neural fate. We have isolated cDNAs for two Xenopus …
activators that can commit cells to a neural fate. We have isolated cDNAs for two Xenopus …
Fringe modulates Notch–ligand interactions
The Notch family of transmembrane receptor proteins mediate developmental cell-fate
decisions, and mutations in mammalian Notch genes have been implicated in leukaemia …
decisions, and mutations in mammalian Notch genes have been implicated in leukaemia …