Deregulation of the cell cycle machinery, which has been linked to dysregulation of cyclin-
dependent kinases (CDKs), is a defining characteristic of cancer, eventually promoting …

Chemotherapy is an important therapeutic approach for the treatment of cancer. Currently,
many anticancer drugs are available in the market that plays an important role in cancer …

Hybrid molecules, furnished by combining two or more pharmacophores is an emerging
concept in the field of medicinal chemistry and drug discovery that has attracted substantial …

Alzheimer's disease (AD) is the most common form of dementia characterized by presence
of extracellular amyloid plaques and intracellular neurofibrillary tangles composed of tau …

Histone deacetylases (HDACs) catalyze the hydrolysis of acetyl-l-lysine side chains in
histones and non-histones, which are key to epigenetic regulation in humans. Targeting …

In an attempt to develop potent anti-tubulin agents against most dreadful disease cancer, a
library of 28 novel triazole tethered isatin-coumarin hybrids were synthesized by click …

Many foods contain appreciable levels of engineered nanomaterials (ENMs)(diameter< 100
nm) that may be either intentionally or unintentionally added. These ENMs vary considerably …

Cyclin-dependent kinases (CDKs) are an important and emerging class of drug targets for
which many small-molecule inhibitors have been developed. However, there is often …

Kee** in view the confines allied with presently accessible antitumor agents and success
of C 5-curcuminoid based bifunctional hybrids as novel antitubulin agnets, molecular …

Abstract Design, synthesis, structural elucidation, and investigation of cytotoxic and
antimicrobial activity, butyrylcholinesterase (BChE), and acetylcholinesterase (AChE) …