Interleukin-15 (IL-15) is a cytokine that belongs to the interleukin-2 (IL-2) family and is
essential for the development, proliferation, and activation of immune cells, including natural …

Simple Summary Non-small cell lung cancer treatment has undergone a revolution in the
past decade owing to the discovery of mutations that drive carcinogenesis and the …

Macrophages are ancient, phagocytic immune cells thought to have their origins 500 million
years ago in metazoan phylogeny. The understanding of macrophages has evolved to …

Spontaneous cancers in companion dogs are robust models of human disease. Tracking
tumor-specific immune responses in these models requires reagents to perform species …

Osteosarcoma, a malignant bone tumor predominantly affecting children and adolescents,
presents significant therapeutic challenges, particularly in metastatic or recurrent cases …

Companion dogs have served an important role in cancer immunotherapy research. Sharing
similar environments and diets with humans, dogs naturally develop many of the same …

Clinical care of osteosarcoma (OSA) in companion dogs has been relatively static during the
past 20 years. The disease of OSA can be described as one of “life and limb.” The limb pain …

Simple Summary Laboratory experiments studying solid tumors are limited by the inability to
adequately model the tumor microenvironment and important immune interactions. Immune …

Fig. 8.1. Cancer Immunotherapy. Page 1 Fig. 8.1. Cancer Immunotherapy. Page 2 8 Cancer
Immunotherapy NICOLA MASON 1* AND STEVEN DOW 2* 1University of Pennsylvania …

Osteosarcoma (OSA) is the most common pediatric malignant bone tumor. Although surgery
together with neoadjuvant/adjuvant chemotherapy has improved survival for localized OSA …