The nature and neurobiology of fear and anxiety: State of the science and opportunities for accelerating discovery
Fear and anxiety play a central role in mammalian life, and there is considerable interest in
clarifying their nature, identifying their biological underpinnings, and determining their …
clarifying their nature, identifying their biological underpinnings, and determining their …
The paraventricular nucleus of the thalamus as an integrating and relay node in the brain anxiety network
GJ Kirouac - Frontiers in Behavioral Neuroscience, 2021 - frontiersin.org
The brain anxiety network is composed of a number of interconnected cortical regions that
detect threats and execute appropriate defensive responses via projections to the shell of …
detect threats and execute appropriate defensive responses via projections to the shell of …
Brain disorders? Not really: Why network structures block reductionism in psychopathology research
In the past decades, reductionism has dominated both research directions and funding
policies in clinical psychology and psychiatry. The intense search for the biological basis of …
policies in clinical psychology and psychiatry. The intense search for the biological basis of …
The overlap** neurobiology of induced and pathological anxiety: a meta-analysis of functional neural activation
Objective: Although anxiety can be an adaptive response to unpredictable threats,
pathological anxiety disorders occur when symptoms adversely affect daily life. Whether or …
pathological anxiety disorders occur when symptoms adversely affect daily life. Whether or …
Anxious individuals shift emotion control from lateral frontal pole to dorsolateral prefrontal cortex
Anxious individuals consistently fail in controlling emotional behavior, leading to excessive
avoidance, a trait that prevents learning through exposure. Although the origin of this failure …
avoidance, a trait that prevents learning through exposure. Although the origin of this failure …
Extrahypothalamic oxytocin neurons drive stress-induced social vigilance and avoidance
N Duque-Wilckens, LY Torres… - Proceedings of the …, 2020 - National Acad Sciences
Oxytocin increases the salience of both positive and negative social contexts and it is
thought that these diverse actions on behavior are mediated in part through circuit-specific …
thought that these diverse actions on behavior are mediated in part through circuit-specific …
Understanding anxiety symptoms as aberrant defensive responding along the threat imminence continuum
R Abend - Neuroscience & Biobehavioral Reviews, 2023 - Elsevier
Threat-anticipatory defensive responses have evolved to promote survival in a dynamic
world. While inherently adaptive, aberrant expression of defensive responses to potential …
world. While inherently adaptive, aberrant expression of defensive responses to potential …
Anxiety and the neurobiology of temporally uncertain threat anticipation
J Hur, JF Smith, KA DeYoung… - Journal of …, 2020 - Soc Neuroscience
When extreme, anxiety—a state of distress and arousal prototypically evoked by uncertain
danger—can be debilitating. Uncertain anticipation is a shared feature of situations that elicit …
danger—can be debilitating. Uncertain anticipation is a shared feature of situations that elicit …
The amygdala and depression: A sober reconsideration
Depressive disorders are a leading cause of global disability, afflicting approximately 280
million individuals worldwide each year (1). In the United States, more than one in five …
million individuals worldwide each year (1). In the United States, more than one in five …
Robust BOLD responses to faces but not to conditioned threat: challenging the amygdala's reputation in human fear and extinction learning
Most of our knowledge about human emotional memory comes from animal research. Based
on this work, the amygdala is often labeled the brain's “fear center”, but it is unclear to what …
on this work, the amygdala is often labeled the brain's “fear center”, but it is unclear to what …