It has become increasingly difficult to find an area of cell biology in which lipids do not have
important, if not key, roles as signalling and regulatory molecules. The rapidly expanding …

The extensive diversity of membrane lipids is rarely appreciated by cell and molecular
biologists. Although most researchers are familiar with the three main classes of lipids in …

Amyloid β-peptide (Aβ), the pathogenic agent of Alzheimer disease, is a physiological
metabolite whose levels are constantly controlled in normal brain. Recent studies have …

Acid sphingomyelinase (ASM) is an important lipid-metabolizing enzyme cleaving
sphingomyelin to ceramide, mainly within lysosomes. Acid ceramidase (AC) further …

Our understanding of the functions of ceramide signaling has advanced tremendously over
the past decade. In this review, we focus on the roles and regulation of neutral …

The fibrotic process could be easily defined as a pathological excess of extracellular matrix
deposition, leading to disruption of tissue architecture and eventually loss of function; …

The plasma membrane (PM) is a major resource for production of bioactive lipids and
contains a large proportion of the cellular sphingomyelin (SM) content. Consequently, the …

Sphingomyelin (SM) can be converted into ceramide (Cer) by neutral sphingomyelinase
(NSM) and acid sphingomyelinase (ASM). Cer is a second messenger of lipids and can …

Ceramide, a bioactive lipid, has been extensively studied and identified as an essential
bioactive molecule in mediating cellular signaling pathways. Sphingomyelinase …

The neutral sphingomyelinases (N-SMases) are considered major candidates for mediating
the stress-induced production of ceramide, and N-SMase activity has been identified …