Despite considerable progress in genome-and proteome-based high-throughput screening
methods and in rational drug design, the increase in approved drugs in the past decade did …

In this review, it is our aim 1) to describe the high diversity in molecular and structural
antioxidant defenses against oxidative stress in animals, 2) to extend the traditional concept …

High-throughput techniques are leading to an explosive growth in the size of biological
databases and creating the opportunity to revolutionize our understanding of life and …

Detecting community structure is fundamental for uncovering the links between structure and
function in complex networks and for practical applications in many disciplines such as …

Although widely used in practice, the behavior and accuracy of the popular module
identification technique called modularity maximization is not well understood in practical …

Metabolism is a vital cellular process, and its malfunction is a major contributor to human
disease. Metabolic networks are complex and highly interconnected, and thus systems-level …

Genome sequences are now available that enable us to determine the biological
components that make up a cell or an organism. The discipline of systems biology examines …

Modularity plays a fundamental role in the prediction of the behavior of a system from the
behavior of its components, guaranteeing that the properties of individual components do …

Most diseases are the consequence of the breakdown of cellular processes, but the
relationships among genetic/epigenetic defects, the molecular interaction networks …

Epistatic interactions, manifested in the effects of mutations on the phenotypes caused by
other mutations, may help uncover the functional organization of complex biological …