Cell–matrix and cell–cell interaction mechanics in guiding migration
Physical properties of tissue are increasingly recognised as major regulatory cues affecting
cell behaviours, particularly cell migration. While these properties of the extracellular matrix …
cell behaviours, particularly cell migration. While these properties of the extracellular matrix …
Forcing the code: tension modulates signaling to drive morphogenesis and malignancy
Abstract Development and disease are regulated by the interplay between genetics and the
signaling pathways stimulated by morphogens, growth factors, and cytokines. Experimental …
signaling pathways stimulated by morphogens, growth factors, and cytokines. Experimental …
T cells use focal adhesions to pull themselves through confined environments
A Caillier, D Oleksyn, DJ Fowell, J Miller… - Journal of Cell …, 2024 - rupress.org
Immune cells are highly dynamic and able to migrate through environments with diverse
biochemical and mechanical compositions. Their migration has classically been defined as …
biochemical and mechanical compositions. Their migration has classically been defined as …
High-motility pro-tumorigenic monocytes drive macrophage enrichment in the tumor microenvironment
Enrichment of tumor-associated macrophages (TAMΦs) in the tumor microenvironment
correlates with worse clinical outcomes in triple-negative breast cancer (TNBC) patients …
correlates with worse clinical outcomes in triple-negative breast cancer (TNBC) patients …