Nitric Oxide (NO) is a potent signaling molecule involved in the regulation of various cellular
mechanisms and pathways under normal and pathological conditions. NO production, its …

During neuronal activity in the brain, extracellular K+ rises and is subsequently removed to
prevent a widespread depolarization. One of the key players in regulating extracellular K+ is …

Several disorders have been associated with mutations in Na, K-ATPase α isoforms (rapid-
onset dystonia parkinsonism, familial hemiplegic migraine type-2), as well as reduction in …

Stress is triggered by numerous unexpected environmental, social or pathological stimuli
occurring during the life of animals, including humans, which determine changes in all of …

Control over the Na, K-ATPase function plays a central role in adaptation of the organisms to
hypoxic and anoxic conditions. As the enzyme itself does not possess O2 binding sites its …

Neuronal signaling in the central nervous system (CNS) associates with release of K+ into
the extracellular space resulting in transient increases in [K+] o. This elevated K+ is swiftly …

Purpose. To review the involvement of the ion transporter Na+/K+-ATPase (NaK) in the
migration and proliferation of glioma cells. Preliminary studies indicate that NaK α 1 subunits …

Decreased Na+, K+-ATPase (NKA) activity causes energy deficiency, which is commonly
observed in neurodegenerative diseases. The NKA is constituted of three subunits: α, β, and …

Despite major advances in the management of malignant gliomas of which glioblastomas
represent the ultimate grade of malignancy, they remain characterized by dismal prognoses …

Excitotoxicity, oxidative stress, and neuro-inflammation underlie the pathogenesis of
neurodegenerative brain disorders. Although L-glutamate is the prime excitatory …