Exposure of biological molecules to oxidants is inevitable and therefore commonplace.
Oxidative stress in cells arises from both external agents and endogenous processes that …

Reactive oxygen, nitrogen, and sulfur species, referred to as ROS, RNS, and RSS,
respectively, are produced during normal cell function and in response to various stimuli. An …

NPR1 is an essential regulator of plant systemic acquired resistance (SAR), which confers
immunity to a broad-spectrum of pathogens. SAR induction results in accumulation of the …

Changes in redox status have been observed during immune responses in different
organisms, but the associated signaling mechanisms are poorly understood. In plants, these …

Abstract Interleukin 1 (IL-1) is an important mediator of innate immunity but can also promote
inflammatory tissue damage. During chronic infections such as tuberculosis, the beneficial …

Oxidants are produced as a by-product of aerobic metabolism, and organisms ranging from
prokaryotes to mammals have evolved with an elaborate and redundant complement of …

Protein S-nitrosylation constitutes a large part of the ubiquitous influence of nitric oxide on
cellular signal transduction and accumulating evidence indicates important roles for S …

S-Nitrosylation, the redox-based modification of Cys thiol side chains by nitric oxide, is a
common mechanism in signal transduction. Dysregulated S-nitrosylation contributes to a …

Well over 2 decades have passed since the endothelium-derived relaxation factor was
reported to be the gaseous molecule nitric oxide (NO). Although soluble guanylyl cyclase …

Proteins are major targets for oxidative damage due to their abundance and rapid rates of
reaction with a wide range of radicals and excited state species, such as singlet oxygen …