The genetic information of human cells is stored in the context of chromatin, which is
subjected to DNA methylation and various histone modifications. Such a 'language'of …

BACKGROUND Multicellular organisms depend on the precise orchestration of gene
expression to direct embryonic development and to maintain tissue homeostasis through …

Abstract Histone–lysine N-methyltransferase 2 (KMT2) family proteins methylate lysine 4 on
the histone H3 tail at important regulatory regions in the genome and thereby impart crucial …

Interactions between WD40 repeat domain protein 5 (WDR5) and its various partners such
as mixed lineage leukemia (MLL) and c-MYC are essential for sustaining oncogenesis in …

Tri‐methylation of lysine 4 on histone H3 (H3K4me3) is a near‐universal chromatin
modification at the transcription start site of active genes in eukaryotes from yeast to man …

Bromodomains (BRDs) are protein interaction modules that specifically recognize ε-N-lysine
acetylation motifs, a key event in the reading process of epigenetic marks. The 61 BRDs in …

The Saccharomyces cerevisiae Set1/COMPASS was the first histone H3 lysine 4 (H3K4)
methylase identified over 10 years ago. Since then, it has been demonstrated that …

Diffuse large B-cell lymphoma (DLBCL) is the most common form of human lymphoma.
Although a number of structural alterations have been associated with the pathogenesis of …

Autophagy is a conserved process by which cytoplasmic components are degraded by the
lysosome. It is commonly seen as a cytoplasmic event and, until now, nuclear events were …

Post-translational modifications of p53 are critical in modulating its tumor suppressive
functions. Ubiquitylation, for example, plays a major role in dictating p53 stability, subcellular …