Multilevel omics for the discovery of biomarkers and therapeutic targets for stroke

J Montaner, L Ramiro, A Simats, S Tiedt… - Nature Reviews …, 2020 - nature.com
Despite many years of research, no biomarkers for stroke are available to use in clinical
practice. Progress in high-throughput technologies has provided new opportunities to …

Acute stroke biomarkers: are we there yet?

M Dagonnier, GA Donnan, SM Davis… - Frontiers in …, 2021 - frontiersin.org
Background: Distinguishing between stroke subtypes and knowing the time of stroke onset
are critical in clinical practice. Thrombolysis and thrombectomy are very effective treatments …

Detection, diagnosis and treatment of acute ischemic stroke: current and future perspectives

S Patil, R Rossi, D Jabrah, K Doyle - Frontiers in medical technology, 2022 - frontiersin.org
Stroke is one of the leading causes of disability worldwide. Early diagnosis and treatment of
stroke are important for better clinical outcome. Rapid and accurate diagnosis of stroke …

Blood biomarkers for stroke diagnosis and management

J Kamtchum-Tatuene, GC Jickling - Neuromolecular medicine, 2019 - Springer
Biomarkers are objective indicators used to assess normal or pathological processes,
evaluate responses to treatment and predict outcomes. Many blood biomarkers already …

Low plasma ergothioneine levels are associated with neurodegeneration and cerebrovascular disease in dementia

LY Wu, IK Cheah, JR Chong, YL Chai, JY Tan… - Free Radical Biology …, 2021 - Elsevier
Ergothioneine (ET) is a dietary amino-thione with strong antioxidant and cytoprotective
properties and has possible therapeutic potential for neurodegenerative and vascular …

Blood biomarkers to differentiate ischemic and hemorrhagic strokes

A Bustamante, A Penalba, C Orset, L Azurmendi… - Neurology, 2021 - AAN Enterprises
Objective To validate a panel of blood biomarkers to differentiate between ischemic stroke
(IS) and intracerebral hemorrhage (ICH) in patients with suspected stroke. Methods Patients …

Intracerebral haemorrhage—mechanisms, diagnosis and prospects for treatment and prevention

DJ Seiffge, S Fandler-Höfler, Y Du… - Nature Reviews …, 2024 - nature.com
Intracerebral haemorrhage (ICH) is a devastating condition associated with high mortality
and substantial residual disability among survivors. Effective treatments for the acute stages …

CSF and blood glial fibrillary acidic protein for the diagnosis of Alzheimer's disease: a systematic review and meta-analysis

Y Zou, Y Wang, X Ma, D Mu, J Zhong, C Ma… - Ageing Research …, 2024 - Elsevier
Recently included in the 2024 new revised diagnostic criteria of Alzheimer's disease (AD),
glial fibrillary acidic protein (GFAP) has garnered significant attention. A systematic review …

Ultra-early differential diagnosis of acute cerebral ischemia and hemorrhagic stroke by measuring the prehospital release rate of GFAP

OS Mattila, NJ Ashton, K Blennow… - Clinical …, 2021 - academic.oup.com
Background Plasma glial fibrillary acidic protein (GFAP) and tau are promising markers for
differentiating acute cerebral ischemia (ACI) and hemorrhagic stroke (HS), but their …

Unlocking the potential of stroke blood biomarkers: early diagnosis, ischemic vs. haemorrhagic differentiation and haemorrhagic transformation risk: a comprehensive …

L di Biase, A Bonura, PM Pecoraro… - International Journal of …, 2023 - mdpi.com
Stroke, a complex and heterogeneous disease, is a leading cause of morbidity and mortality
worldwide. The timely therapeutic intervention significantly impacts patient outcomes, but …