[HTML][HTML] Acetyltransferase in cardiovascular disease and aging

MA Keller, M Nakamura - The journal of cardiovascular aging, 2024 - pmc.ncbi.nlm.nih.gov
Acetyltransferases are enzymes that catalyze the transfer of an acetyl group to a substrate, a
modification referred to as acetylation. Loss-of-function variants in genes encoding …

[HTML][HTML] YAP K236 acetylation facilitates its nucleic export and deprived the protection against cardiac hypertrophy in mice

P Wang, L Wang, C Liu, Y Hu, G Feng, Z Lian… - Pharmacological …, 2025 - Elsevier
The subcellular localization of Yes-associated protein (YAP) is dynamically regulated by
post-transcriptional modifications, critically influencing cardiac function. Despite its …

Spotlight on YAP: Unlocking New Insights to Overcome the Barriers to Heart Regeneration

N Velayutham, RT Lee - Circulation, 2025 - ahajournals.org
The adult mammalian heart has low capacity for self-renewal; this is insufficient to replace
the large number of cardiomyocytes lost during injury and can ultimately lead to heart failure …