Bioelectric signaling: Reprogrammable circuits underlying embryogenesis, regeneration, and cancer

M Levin - Cell, 2021 - cell.com
How are individual cell behaviors coordinated toward invariant large-scale anatomical
outcomes in development and regeneration despite unpredictable perturbations …

Darwin's agential materials: evolutionary implications of multiscale competency in developmental biology

M Levin - Cellular and Molecular Life Sciences, 2023 - Springer
A critical aspect of evolution is the layer of developmental physiology that operates between
the genotype and the anatomical phenotype. While much work has addressed the evolution …

Technological approach to mind everywhere: an experimentally-grounded framework for understanding diverse bodies and minds

M Levin - Frontiers in systems neuroscience, 2022 - frontiersin.org
Synthetic biology and bioengineering provide the opportunity to create novel embodied
cognitive systems (otherwise known as minds) in a very wide variety of chimeric …

Competency in navigating arbitrary spaces as an invariant for analyzing cognition in diverse embodiments

C Fields, M Levin - Entropy, 2022 - mdpi.com
One of the most salient features of life is its capacity to handle novelty and namely to thrive
and adapt to new circumstances and changes in both the environment and internal …

Synthetic morphology with agential materials

J Davies, M Levin - Nature Reviews Bioengineering, 2023 - nature.com
Bioengineering can address many important needs, from transformative biomedicine to
environmental remediation. In addition to practical applications, the construction of new …

Bioelectric networks: the cognitive glue enabling evolutionary scaling from physiology to mind

M Levin - Animal Cognition, 2023 - Springer
Each of us made the remarkable journey from mere matter to mind: starting life as a
quiescent oocyte (“just chemistry and physics”), and slowly, gradually, becoming an adult …

[HTML][HTML] Bioelectric signaling in regeneration: mechanisms of ionic controls of growth and form

KA McLaughlin, M Levin - Developmental biology, 2018 - Elsevier
The ability to control pattern formation is critical for the both the embryonic development of
complex structures as well as for the regeneration/repair of damaged or missing tissues and …

The bioelectric code: An ancient computational medium for dynamic control of growth and form

M Levin, CJ Martyniuk - Biosystems, 2018 - Elsevier
What determines large-scale anatomy? DNA does not directly specify geometrical
arrangements of tissues and organs, and a process of encoding and decoding for …

Top-down models in biology: explanation and control of complex living systems above the molecular level

G Pezzulo, M Levin - Journal of The Royal Society …, 2016 - royalsocietypublishing.org
It is widely assumed in developmental biology and bioengineering that optimal
understanding and control of complex living systems follows from models of molecular …

Collective intelligence: A unifying concept for integrating biology across scales and substrates

P McMillen, M Levin - Communications Biology, 2024 - nature.com
A defining feature of biology is the use of a multiscale architecture, ranging from molecular
networks to cells, tissues, organs, whole bodies, and swarms. Crucially however, biology is …