Pathogenesis of multiple sclerosis: insights from molecular and metabolic imaging
The mechanisms underlying the pathogenesis of multiple sclerosis induce the changes that
underpin relapse-associated and progressive disability. Disease mechanisms can be …
underpin relapse-associated and progressive disability. Disease mechanisms can be …
The relevance of animal models in multiple sclerosis research
Multiple Sclerosis (MS) is a complex disease with an unknown etiology and no effective
cure, despite decades of extensive research that led to the development of several partially …
cure, despite decades of extensive research that led to the development of several partially …
Sphingosine 1-phosphate receptors and metabolic enzymes as druggable targets for brain diseases
S Grassi, L Mauri, S Prioni, L Cabitta… - Frontiers in …, 2019 - frontiersin.org
The central nervous system is characterized by a high content of sphingolipids and by a high
diversity in terms of different structures. Stage-and cell-specific sphingolipid metabolism and …
diversity in terms of different structures. Stage-and cell-specific sphingolipid metabolism and …
Role of oligodendrocyte dysfunction in demyelination, remyelination and neurodegeneration in multiple sclerosis
AO Dulamea - Multiple Sclerosis: Bench to Bedside: Global …, 2017 - Springer
Oligodendrocytes (OLs) are the myelinating cells of the central nervous system (CNS) during
development and throughout adulthood. They result from a complex and well controlled …
development and throughout adulthood. They result from a complex and well controlled …
Strategies for oligodendrocyte and myelin repair in traumatic CNS injury
A Huntemer-Silveira, N Patil, MA Brickner… - Frontiers in Cellular …, 2021 - frontiersin.org
A major consequence of traumatic brain and spinal cord injury is the loss of the myelin
sheath, a cholesterol-rich layer of insulation that wraps around axons of the nervous system …
sheath, a cholesterol-rich layer of insulation that wraps around axons of the nervous system …
Myelin recovery in multiple sclerosis: the challenge of remyelination
M Podbielska, NL Banik, E Kurowska, EL Hogan - Brain sciences, 2013 - mdpi.com
Multiple sclerosis (MS) is the most common demyelinating and an autoimmune disease of
the central nervous system characterized by immune-mediated myelin and axonal damage …
the central nervous system characterized by immune-mediated myelin and axonal damage …
Naturally occurring auto-antibodies in homeostasis and disease
Antibodies with germline or close to germline configuration exist in vertebrates, and these so-
called 'naturally occurring auto-antibodies'(NAb) are directed to self and altered self …
called 'naturally occurring auto-antibodies'(NAb) are directed to self and altered self …
Natural antibodies, intravenous immunoglobulin and their role in autoimmunity, cancer and inflammation
R Schwartz-Albiez, RC Monteiro… - Clinical & …, 2009 - academic.oup.com
Natural antibodies are produced by B lymphocytes in the absence of external antigen
stimulation. With their ability to recognize self, altered self and foreign antigens, they …
stimulation. With their ability to recognize self, altered self and foreign antigens, they …
Remyelination therapy in multiple sclerosis
DE Harlow, JM Honce, AA Miravalle - Frontiers in neurology, 2015 - frontiersin.org
Multiple sclerosis (MS) is an immune-mediated disorder of the central nervous system that
results in destruction of the myelin sheath that surrounds axons and eventual …
results in destruction of the myelin sheath that surrounds axons and eventual …
Surface plasmon resonance for high‐throughput ligand screening of membrane‐bound proteins
Technologies based on surface plasmon resonance (SPR) have allowed rapid, label‐free
characterization of protein‐protein and protein‐small molecule interactions. SPR has …
characterization of protein‐protein and protein‐small molecule interactions. SPR has …