The tumor microenvironment (TME) is composed of various cell types embedded in an
altered extracellular matrix (ECM). ECM not only serves as a support for tumor cell but also …

The extracellular matrix (ECM) is a significant factor in cancer progression. Collagens, as the
main component of the ECM, are greatly remodeled alongside cancer development. More …

Despite advances in cancer detection and therapy, it has been estimated that the incidence
of cancers will increase, while the mortality rate will continue to remain high, a fact explained …

Fibrosis of visceral organs such as the lungs, heart, kidneys and liver remains a major cause
of morbidity and mortality and is also associated with many other disorders, including cancer …

Pancreatic ductal adenocarcinoma (PDAC) has one of the worst outcomes among cancers
with a 5-years survival rate of below 10%. This is a result of late diagnosis and the lack of …

Fibrotic diseases remain a major cause of morbidity and mortality, yet there are few effective
therapies. The underlying pathology of all fibrotic conditions is the activity of myofibroblasts …

Our overview covers several key areas related to recent results obtained for collagen type VI
and endotrophin (ETP).(1) An introduction to the history of ETP, including how it was …

The cellular microenvironment composition and changes therein play an extremely
important role in cancer development. Changes in the extracellular matrix (ECM), which …

Simple Summary Pancreatic ductal adenocarcinoma (PDAC) is a devastating disease. New
tools which can aid in the understanding of PDAC biology and novel drug development are …

Sarcopenia, the progressive loss of muscle mass and strength, is one of the major health
issues in older adults, given its high prevalence accompanied by huge clinical and …