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Regulation of and challenges in targeting NAD+ metabolism
Nicotinamide adenine dinucleotide, in its oxidized (NAD+) and reduced (NADH) forms, is a
reduction–oxidation (redox) co-factor and substrate for signalling enzymes that have …
reduction–oxidation (redox) co-factor and substrate for signalling enzymes that have …
NAD+ homeostasis in human health and disease
Depletion of nicotinamide adenine dinucleotide (NAD+), a central redox cofactor and the
substrate of key metabolic enzymes, is the causative factor of a number of inherited and …
substrate of key metabolic enzymes, is the causative factor of a number of inherited and …
Healthy aging and muscle function are positively associated with NAD+ abundance in humans
Skeletal muscle is greatly affected by aging, resulting in a loss of metabolic and physical
function. However, the underlying molecular processes and how (lack of) physical activity is …
function. However, the underlying molecular processes and how (lack of) physical activity is …
Immunometabolic rewiring of tubular epithelial cells in kidney disease
Kidney tubular epithelial cells (TECs) have a crucial role in the damage and repair response
to acute and chronic injury. To adequately respond to constant changes in the environment …
to acute and chronic injury. To adequately respond to constant changes in the environment …
Mitochondrial dysfunction in human hypertrophic cardiomyopathy is linked to cardiomyocyte architecture disruption and corrected by improving NADH-driven …
Aims Genetic hypertrophic cardiomyopathy (HCM) is caused by mutations in sarcomere
protein-encoding genes (ie genotype-positive HCM). In an increasing number of patients …
protein-encoding genes (ie genotype-positive HCM). In an increasing number of patients …
[HTML][HTML] NAD precursors cycle between host tissues and the gut microbiome
Nicotinamide adenine dinucleotide (NAD) is an essential redox cofactor in mammals and
microbes. Here we use isotope tracing to investigate the precursors supporting NAD …
microbes. Here we use isotope tracing to investigate the precursors supporting NAD …
Balancing NAD+ deficits with nicotinamide riboside: therapeutic possibilities and limitations
Alterations in cellular nicotinamide adenine dinucleotide (NAD+) levels have been observed
in multiple lifestyle and age-related medical conditions. This has led to the hypothesis that …
in multiple lifestyle and age-related medical conditions. This has led to the hypothesis that …
[HTML][HTML] Advances in NAD-lowering agents for cancer treatment
Nicotinamide adenine dinucleotide (NAD) is an essential redox cofactor, but it also acts as a
substrate for NAD-consuming enzymes, regulating cellular events such as DNA repair and …
substrate for NAD-consuming enzymes, regulating cellular events such as DNA repair and …
The therapeutic perspective of NAD+ precursors in age-related diseases
Nicotinamide adenine dinucleotide (NAD+) is the fundamental molecule that performs
numerous biological reactions and is crucial for maintaining cellular homeostasis. Studies …
numerous biological reactions and is crucial for maintaining cellular homeostasis. Studies …
[HTML][HTML] Nicotinamide Riboside, a Promising Vitamin B3 Derivative for Healthy Aging and Longevity: Current Research and Perspectives
Many studies have suggested that the oxidized form of nicotinamide adenine dinucleotide
(NAD+) is involved in an extensive spectrum of human pathologies, including …
(NAD+) is involved in an extensive spectrum of human pathologies, including …