Autophagosomes are double-membrane vesicles newly formed during autophagy to engulf
a wide range of intracellular material and transport this autophagic cargo to lysosomes (or …

Autophagosome biogenesis involves de novo formation of a membrane that elongates to
sequester cytoplasmic cargo and closes to form a double-membrane vesicle (an …

Macroautophagic clearance of cytosolic materials entails the initiation, growth and closure of
autophagosomes. Cargo triggers the assembly of a web of cargo receptors and core …

To become resistant, cancer cells need to activate and maintain molecular defense
mechanisms that depend on an energy trade-off between resistance and essential functions …

Introduction While the COVID-19 pandemic continues to have a significant global health
impact, rates of maternal to infant vertical transmission remain low (< 5%). Parenchymal …

In 2008, we published the first set of guidelines for standardizing research in autophagy.
Since then, this topic has received increasing attention, and many scientists have entered …

The multispanning membrane protein ATG9A is a scramblase that flips phospholipids
between the two membrane leaflets, thus contributing to the expansion of the phagophore …

Abstract Background Schisandrin B (Sch B), which inhibits hepatic steatosis caused by non-
alcoholic fatty liver disease (NAFLD), is one of the most active dibenzocyclooctadienes …

Lysosomes degrade macromolecules and recycle their nutrient content to support cell
function and survival. However, the machineries involved in lysosomal recycling of many …

Autophagy is a conserved catabolic homeostasis process central for cellular and organismal
health. During autophagy, small single-membrane phagophores rapidly expand into large …