RNA-binding proteins driving the regulatory activity of small non-coding RNAs in bacteria

AP Quendera, AF Seixas, RF Dos Santos… - Frontiers in molecular …, 2020 - frontiersin.org
Small non-coding RNAs (sRNAs) are critical post-transcriptional regulators of gene
expression. Distinct RNA-binding proteins (RBPs) influence the processing, stability and …

Bacterial RNA chaperones and chaperone-like riboregulators: behind the scenes of RNA-mediated regulation of cellular metabolism

K Katsuya-Gaviria, G Paris, T Dendooven… - RNA biology, 2022 - Taylor & Francis
In all domains of life, RNA chaperones safeguard and guide the fate of the cellular RNA
pool. RNA chaperones comprise structurally diverse proteins that ensure proper folding …

A particle size threshold governs diffusion and segregation of PAR-3 during cell polarization

Y Chang, DJ Dickinson - Cell reports, 2022 - cell.com
The actomyosin cortex regulates the localization and function of proteins at the plasma
membrane. Here, we study how membrane binding, cortical movements, and diffusion …

Dynamic refolding of OxyS sRNA by the Hfq RNA chaperone

H Cai, J Roca, YF Zhao, SA Woodson - Journal of molecular biology, 2022 - Elsevier
Abstract The Sm protein Hfq chaperones small non-coding RNAs (sRNAs) in bacteria,
facilitating sRNA regulation of target mRNAs. Hfq acts in part by remodeling the sRNA and …

Small RNAs as fundamental players in the transference of information during bacterial infectious diseases

JJ González Plaza - Frontiers in Molecular Biosciences, 2020 - frontiersin.org
Communication shapes life on Earth. Transference of information has played a paramount
role on the evolution of all living or extinct organisms since the appearance of life. Success …

Structural basis of rotavirus RNA chaperone displacement and RNA annealing

JPK Bravo, K Bartnik, L Venditti… - Proceedings of the …, 2021 - National Acad Sciences
Rotavirus genomes are distributed between 11 distinct RNA molecules, all of which must be
selectively copackaged during virus assembly. This likely occurs through sequence-specific …

Riboregulation in bacteria: From general principles to novel mechanisms of the trp attenuator and its sRNA and peptide products

E Evguenieva‐Hackenberg - Wiley Interdisciplinary Reviews …, 2022 - Wiley Online Library
Gene expression strategies ensuring bacterial survival and competitiveness rely on cis‐and
trans‐acting RNA‐regulators (riboregulators). Among the cis‐acting riboregulators are …

Impacts of small RNAs and their chaperones on bacterial pathogenicity

L Djapgne, AG Oglesby - Frontiers in Cellular and Infection …, 2021 - frontiersin.org
Bacterial small RNAs (sRNAs) are critical post-transcriptional regulators that exert broad
effects on cell physiology. One class of sRNAs, referred to as trans-acting sRNAs, base-pairs …

Switching fatty acid metabolism by an RNA-controlled feed forward loop

M Huber, KS Fröhlich, J Radmer… - Proceedings of the …, 2020 - National Acad Sciences
Hfq (host factor for phage Q beta) is key for posttranscriptional gene regulation in many
bacteria. Hfq's function is to stabilize sRNAs and to facilitate base-pairing with trans …

Intrinsically disordered interaction network in an RNA chaperone revealed by native mass spectrometry

SH Sarni, J Roca, C Du, M Jia, H Li… - Proceedings of the …, 2022 - National Acad Sciences
RNA-binding proteins contain intrinsically disordered regions whose functions in RNA
recognition are poorly understood. The RNA chaperone Hfq is a homohexamer that contains …