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Improved green and red GRAB sensors for monitoring spatiotemporal serotonin release in vivo
Epilepsy insights revealed by intravital functional optical imaging
Despite an abundance of pharmacologic and surgical epilepsy treatments, there remain
millions of patients suffering from poorly controlled seizures. One approach to closing this …
millions of patients suffering from poorly controlled seizures. One approach to closing this …
[HTML][HTML] Local feedback inhibition tightly controls rapid formation of hippocampal place fields
Hippocampal place cells underlie spatial navigation and memory. Remarkably, CA1
pyramidal neurons can form new place fields within a single trial by undergoing rapid …
pyramidal neurons can form new place fields within a single trial by undergoing rapid …
Dual-color GRAB sensors for monitoring spatiotemporal serotonin release in vivo
The serotonergic system plays important roles in both physiological and pathological
processes, and is a widely used therapeutic target for many psychiatric disorders. Although …
processes, and is a widely used therapeutic target for many psychiatric disorders. Although …
Repeated episodes of postictal hypoxia are a mechanism for interictal cognitive impairments
Comorbidities during the period between seizures present a significant challenge for
individuals with epilepsy. Despite their clinical relevance, the pathophysiology of the …
individuals with epilepsy. Despite their clinical relevance, the pathophysiology of the …
Seizure-induced neutrophil adhesion in brain capillaries leads to a decrease in postictal cerebral blood flow
Cerebral hypoperfusion has been proposed as a potential cause of postictal neurological
dysfunction in epilepsy, but its underlying mechanism is still unclear. We show that a 30 …
dysfunction in epilepsy, but its underlying mechanism is still unclear. We show that a 30 …
Imaging the endocannabinoid signaling system
The endocannabinoid (eCB) system is one of the most widespread neuromodulatory
systems in the mammalian brain, with a multifaceted role in functions ranging from …
systems in the mammalian brain, with a multifaceted role in functions ranging from …