The interplay between extracellular matrix (ECM) stiffness and the tumor microenvironment
is increasingly recognized as a critical factor in cancer progression and the efficacy of …

In recent years, the biological role of changes in physical factors in carcinogenesis and
progression has attracted increasing attention. Matrix stiffness, also known as ECM stress, is …

How cells sense tissue stiffness to guide cell migration is a fundamental question in
development, fibrosis and cancer. Although durotaxis—cell migration towards increasing …

Alteration in the density and composition of extracellular matrix (ECM) occurs in tumors. The
alterations toward both stiffness and degradation are contributed to tumor growth and …

Simple Summary Matrix stiffness is recognized as a critical factor in cancer progression.
Recent studies have shown that matrix stiffening is caused by the accumulation, contraction …

Acting as a bridge between the cytoskeleton of the cell and the extra cellular matrix (ECM),
the cell-ECM adhesions with integrins at their core, play a major role in cell signalling to …

Ferroptosis is a recently discovered form of regulated cell death that is morphologically,
genetically, and biochemically distinct from apoptosis and necroptosis, and its potential use …

Cells generate mechanical forces (traction forces, TFs) while interacting with the
extracellular matrix or neighbouring cells. Forces are generated by both cells and …

Regulatory T cells (Tregs) represent a low number of T‐cell population under normal
conditions, and they play key roles for maintaining immune system in homeostasis. The …

Tumor microenvironment (TME) is a host for a complex network of heterogeneous stromal
cells with overlap** or opposing functions depending on the dominant signals within this …