Turnitin
降AI改写
早检测系统
早降重系统
Turnitin-UK版
万方检测-期刊版
维普编辑部版
Grammarly检测
Paperpass检测
checkpass检测
PaperYY检测
DYRK1A inhibitors for disease therapy: Current status and perspectives
Dual-specificity tyrosine phosphorylation-regulated kinase 1 A (DYRK1A) is a conserved
protein kinase that plays essential roles in various biological processes. It is located in the …
protein kinase that plays essential roles in various biological processes. It is located in the …
A review on synthetic inhibitors of dual-specific tyrosine phosphorylation-regulated kinase 1A (DYRK1A) for the treatment of Alzheimer's disease (AD)
Alzheimer's disease (AD) is a complex disorder that is influenced by a number of variables,
such as age, gender, environmental factors, disease, lifestyle, infections, and many more …
such as age, gender, environmental factors, disease, lifestyle, infections, and many more …
Novel benzothiazole derivatives as multitargeted-directed ligands for the treatment of Alzheimer's disease
DE Hafez, M Dubiel, G La Spada, M Catto… - Journal of Enzyme …, 2023 - Taylor & Francis
Neurodegenerative diseases such as Alzheimer's disease (AD) are multifactorial with
several different pathologic mechanisms. Therefore, it is assumed that multitargeted-directed …
several different pathologic mechanisms. Therefore, it is assumed that multitargeted-directed …
EGCG-like non-competitive inhibitor of DYRK1A rescues cognitive defect in a down syndrome model
Overexpression of the chromosome 21 DYRK1A gene induces morphological defects and
cognitive impairments in individuals with Down syndrome (DS) and in DS mice models …
cognitive impairments in individuals with Down syndrome (DS) and in DS mice models …
Discovery of novel 6-hydroxybenzothiazole urea derivatives as dual Dyrk1A/α-synuclein aggregation inhibitors with neuroprotective effects
A role of Dyrk1A in the progression of Down syndrome–related Alzheimer's disease (AD) is
well supported. However, the involvement of Dyrk1A in the pathogenesis of Parkinson's …
well supported. However, the involvement of Dyrk1A in the pathogenesis of Parkinson's …
Regiodivergent Synthesis of Brominated Pyridylthiophenes by Overriding the Inherent Substrate Bias
A regiocontrolled functionalization of a pyridylthiophene scaffold was accomplished.
Regioselectivity for deprotonation of the pyridylthiophene was switched by changing the …
Regioselectivity for deprotonation of the pyridylthiophene was switched by changing the …
From Dyrk1A inhibitors to a novel class of antiviral agents: Targeting Enterovirus EV-A71 with 2-aryl-substituted thiophene scaffolds
PM Keddis, TKM Tu, H Scherer, AM Kany… - European Journal of …, 2025 - Elsevier
Abstract Enterovirus A71 (EV-A71) is a major causative agent of hand, foot, and mouth
disease (HFMD) especially in children. The majority of EV-A71 cases are mild, however …
disease (HFMD) especially in children. The majority of EV-A71 cases are mild, however …
Discovery of novel 5-methoxybenzothiophene hydrazides as metabolically stable Clk1 inhibitors with high potency and unprecedented Clk1 isoenzyme selectivity
Clk1 kinase is a key modulator of the pre-mRNA alternative splicing machinery which has
been proposed as a promising target for treatment of various tumour types, Duchenne's …
been proposed as a promising target for treatment of various tumour types, Duchenne's …
Development of novel amide–derivatized 2, 4-bispyridyl thiophenes as highly potent and selective Dyrk1A inhibitors. Part II: Identification of the cyclopropylamide …
Dual-specificity tyrosine phosphorylation-regulated kinase 1A (Dyrk1A) is a potential target
in Alzheimer's disease (AD) because of the established correlation between its over …
in Alzheimer's disease (AD) because of the established correlation between its over …
Development of novel conformationally restricted selective Clk1/4 inhibitors through creating an intramolecular hydrogen bond involving an imide linker
As prime regulators of pre-mRNA alternative splicing, different Clk isoforms were found to be
overexpressed in various tumour types and have received much attention recently as …
overexpressed in various tumour types and have received much attention recently as …