The last decades have seen a tremendous expanse in the application of C H activation of
many different substrate classes, including the invaluable indole scaffold. Following the …

Increasing evidence suggests that metabolites produced by the gut microbiota play a crucial
role in host–microbe interactions. Dietary tryptophan ingested by the host enters the gut …

New types of antidiabetic agents are continually needed with diabetes becoming the
epidemic in the world. Indole alkaloids play an important role in natural products owing to …

De novo drug design aims to generate molecules from scratch that possess specific
chemical and pharmacological properties. We present a computational approach utilizing …

Excessive energy intake and reduced energy expenditure drive the development of insulin
resistance and metabolic diseases such as obesity and type 2 diabetes mellitus. Metabolic …

Peroxisome proliferator-activated receptors (PPARs) compose a family of nuclear receptors
that mediate the effects of lipidic ligands at the transcriptional level. In this review, we …

The gut microbiota has emerged as an integral factor that impacts host metabolism and has
been suggested to play a vital role in metabolic diseases such as obesity, insulin resistance …

Context: We have previously shown that an antidepressant-like effect of probiotics in rats
was associated with a higher plasma level of the microbial tryptophan metabolite indole-3 …

Recently, it has been established that the human resident microbiota plays key roles in
health maintenance. Therefore, it has become an emerging prevention and treatment target …

Highlights•Drug repurposing may be a novel approach towards develo** adjunct therapy
for stroke.•Drug repurposing avoids time and expenses associated with new drug-discovery …