[HTML][HTML] Current perspectives in pulmonary surfactant—inhibition, enhancement and evaluation

YY Zuo, RAW Veldhuizen, AW Neumann… - … et Biophysica Acta (BBA …, 2008 - Elsevier
Pulmonary surfactant (PS) is a complicated mixture of approximately 90% lipids and 10%
proteins. It plays an important role in maintaining normal respiratory mechanics by reducing …

Pulmonary complications of mechanical ventilation in neonates

JD Miller, WA Carlo - Clinics in perinatology, 2008 - Elsevier
Mechanical ventilation is necessary and life saving in many neonates. Most complications
are inherent to this intervention and cannot be confused with iatrogenic errors in judgment or …

[HTML][HTML] Role of lipid ordered/disordered phase coexistence in pulmonary surfactant function

C Casals, O Cañadas - Biochimica et Biophysica Acta (BBA) …, 2012 - Elsevier
The respiratory epithelium has evolved to produce a complicated network of extracellular
membranes that are essential for breathing and, ultimately, survival. Surfactant membranes …

Positive pressure ventilation: what is the real cost?

N Soni, P Williams - British journal of anaesthesia, 2008 - academic.oup.com
Positive pressure ventilation is a radical departure from the physiology of breathing
spontaneously. The immediate physiological consequences of positive pressure ventilation …

Pulmonary surfactant function is abolished by an elevated proportion of cholesterol

L Gunasekara, S Schürch, WM Schoel, K Nag… - … et Biophysica Acta (BBA …, 2005 - Elsevier
A molecular film of pulmonary surfactant strongly reduces the surface tension of the lung
epithelium–air interface. Human pulmonary surfactant contains 5–10% cholesterol by mass …

Benzalkonium chloride and cetylpyridinium chloride induce apoptosis in human lung epithelial cells and alter surface activity of pulmonary surfactant monolayers

S Kanno, S Hirano, H Kato, M Fukuta, T Mukai… - Chemico-Biological …, 2020 - Elsevier
Quaternary ammonium compounds (eg, benzalkonium chloride (BAC) and cetylpyridinium
chloride (CPC)) constitute a group of cationic surfactants are widely used for personal …

Effect of cholesterol on the biophysical and physiological properties of a clinical pulmonary surfactant

E Keating, L Rahman, J Francis, A Petersen… - Biophysical journal, 2007 - cell.com
Pulmonary surfactant is a complex mixture of lipids and proteins that forms a surface-active
film at the air-water interface of alveoli capable of reducing surface tension to near 0mN/m …

An elevated level of cholesterol impairs self-assembly of pulmonary surfactant into a functional film

Z Leonenko, S Gill, S Baoukina, L Monticelli… - Biophysical journal, 2007 - cell.com
In adult respiratory distress syndrome, the primary function of pulmonary surfactant to
strongly reduce the surface tension of the air-alveolar interface is impaired, resulting in …

The molecular mechanism of monolayer-bilayer transformations of lung surfactant from molecular dynamics simulations

S Baoukina, L Monticelli, M Amrein, DP Tieleman - Biophysical journal, 2007 - cell.com
The aqueous lining of the lung surface exposed to the air is covered by lung surfactant, a
film consisting of lipid and protein components. The main function of lung surfactant is to …

1, 2-Dimyristoyl-sn-glycero-3-phosphoglycerol (DMPG) monolayers: influence of temperature, pH, ionic strength and binding of alkaline earth cations

P Garidel, A Blume - Chemistry and physics of lipids, 2005 - Elsevier
Ion binding and lipid ionization of the acidic phospholipid 1, 2-dimyristoyl-sn-glycero-3-
phosphoglycerol (DMPG) in monolayers was studied by measuring the lateral pressure Π as …