Animals receive environmental stimuli from neural signals in order to produce hormones that
control immune responses. Glucocorticoids (GCs) are a group of steroid hormones …

Glucocorticoids are small lipophilic compounds that mediate their many biological effects by
binding an intracellular receptor (GR) that, in turn, translocates to the nucleus and directly or …

Interleukin-5 is produced by a number of cell types, and is responsible for the maturation
and release of eosinophils in the bone marrow. In humans, interleukin-5 is a very selective …

Animals have evolved circadian rhythms to adapt to the 24-h day-night cycle. Circadian
rhythms are controlled by molecular clocks in the brain and periphery, which is driven by …

Eotaxin is a potent and specific eosinophil chemoattractant that is mobilized in the
respiratory epithelium after allergic stimulation. Pulmonary levels of eotaxin mRNA are …

The purpose of this brief review is to give an overview of the current literature on the
influence of glucocorticoids (steroids)" on human eosinophils. This cell type is believed to be …

TREATMENT OF INFLAMMATORY DISEASE important. Glucocorticosteroids inhibit the
transcription of several cytokines and chemokines that Inflammation is a central feature of …

Glucocorticoids are the most effective antiinflammatory drugs used in the treatment of
asthma. They act by binding to a specific receptor (GR) that, upon activation, translocates to …

We believe that there are the following four classes of glucocorticoid-sensitive cytokines that
are involved in cell recruitment:(1) those that activate endothelium nonspecifically;(2) those …

Pulmonary inflammation with eosinophil (EOs) infiltration is a prominent feature of allergic
respiratory diseases such as asthma. In order to study the cellular response during the …