Vascular tone of resistance arteries and arterioles determines peripheral vascular
resistance, contributing to the regulation of blood pressure and blood flow to, and within the …

Faraci, Frank M., and Donald D. Heistad. Regulation of the Cerebral Circulation: Role of
Endothelium and Potassium Channels. Physiol. Rev. 78: 53–97, 1998.—Several new …

Nitric oxide (NO)-induced relaxation is associated with increased levels of cGMP in vascular
smooth muscle cells. However, the mechanism by which cGMP causes relaxation is …

The properties and roles of ATP-sensitive (KATP) and inwardly rectifying (KIR) potassium
channels are reviewed. Potassium channels regulate the membrane potential of smooth …

Guanosine-3', 5'-cyclic monophosphate (cGMP)-dependent protein kinase (cGMP-PK) plays
a central role in the mediation of the vasodilator response to nitric oxide (NO) and other …

Blood flow and blood pressure are determined by an integration of reflex, humoral, and local
vascular control mechanisms. Knowledge of these mechanisms has mushroomed over the …

Endothelial-dependent relaxation of vascular smooth muscle cells evoked by a number of
agonists, including cholinomimetics and substance P, is often accompanied by an increase …

ATP-sensitive potassium (KATP) channels are present in the surface and internal
membranes of cardiac, skeletal, and smooth muscle cells and provide a unique feedback …

ATP‐sensitive potassium channels (KATP) are present in vascular smooth muscle cells and
play important roles in the vascular responses to a variety of pharmacological and …

1. Nitric oxide (NO) relaxes vascular smooth muscle (VSM) by mechanisms which are not
fully understood. One possibility is that NO hyperpolarizes membranes, thereby diminishing …