[HTML][HTML] Type I and type III interferons–induction, signaling, evasion, and application to combat COVID-19
A Park, A Iwasaki - Cell host & microbe, 2020 - cell.com
Coronavirus disease 2019 (COVID-19) is a global pandemic caused by severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2). Without approved antiviral therapeutics …
respiratory syndrome coronavirus 2 (SARS-CoV-2). Without approved antiviral therapeutics …
Type I and III interferon responses in SARS-CoV-2 infection
Abstract Coronavirus disease 2019 (COVID-19), the current pandemic disease, is caused by
severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Type I and III …
severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Type I and III …
A prenylated dsRNA sensor protects against severe COVID-19
INTRODUCTION Interferons (IFNs) are cytokines that are rapidly deployed in response to
invading pathogens. By initiating a signaling cascade that stimulates the expression of …
invading pathogens. By initiating a signaling cascade that stimulates the expression of …
The molecular virology of coronaviruses
E Hartenian, D Nandakumar, A Lari, M Ly… - Journal of Biological …, 2020 - ASBMB
Few human pathogens have been the focus of as much concentrated worldwide attention as
severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the cause of COVID-19. Its …
severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the cause of COVID-19. Its …
SARS-CoV-2 nsp13, nsp14, nsp15 and orf6 function as potent interferon antagonists
CK Yuen, JY Lam, WM Wong, LF Mak… - Emerging microbes & …, 2020 - Taylor & Francis
ABSTRACT The Coronavirus disease 2019 (COVID-19), which is caused by the novel SARS-
CoV-2 virus, is now causing a tremendous global health concern. Since its first appearance …
CoV-2 virus, is now causing a tremendous global health concern. Since its first appearance …
SARS-CoV-2 Orf6 hijacks Nup98 to block STAT nuclear import and antagonize interferon signaling
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the causative agent of
the ongoing coronavirus disease 2019 (COVID-19) pandemic that is a serious global health …
the ongoing coronavirus disease 2019 (COVID-19) pandemic that is a serious global health …
A tug-of-war between severe acute respiratory syndrome coronavirus 2 and host antiviral defence: lessons from other pathogenic viruses
ABSTRACT World Health Organization has declared the ongoing outbreak of coronavirus
disease 2019 (COVID-19) a Public Health Emergency of International Concern. The virus …
disease 2019 (COVID-19) a Public Health Emergency of International Concern. The virus …
SARS-CoV-2 induces double-stranded RNA-mediated innate immune responses in respiratory epithelial-derived cells and cardiomyocytes
Y Li, DM Renner, CE Comar… - Proceedings of the …, 2021 - National Acad Sciences
Coronaviruses are adept at evading host antiviral pathways induced by viral double-
stranded RNA, including interferon (IFN) signaling, oligoadenylate synthetase–ribonuclease …
stranded RNA, including interferon (IFN) signaling, oligoadenylate synthetase–ribonuclease …
Overview of lethal human coronaviruses
B Chen, EK Tian, B He, L Tian, R Han… - Signal transduction and …, 2020 - nature.com
Coronavirus infections of multiple origins have spread to date worldwide, causing severe
respiratory diseases. Seven coronaviruses that infect humans have been identified: HCoV …
respiratory diseases. Seven coronaviruses that infect humans have been identified: HCoV …
SARS-CoV-2 and innate immunity: the good, the bad, and the “goldilocks”
An ancient conflict between hosts and pathogens has driven the innate and adaptive arms of
immunity. Knowledge about this interplay can not only help us identify biological …
immunity. Knowledge about this interplay can not only help us identify biological …