Biological functions of mesenchymal stem cells and clinical implications

A Naji, M Eitoku, B Favier, F Deschaseaux… - Cellular and Molecular …, 2019 - Springer
Mesenchymal stem cells (MSCs) are isolated from multiple biological tissues—adult bone
marrow and adipose tissues and neonatal tissues such as umbilical cord and placenta. In …

Adult mesenchymal stem cells for tissue engineering versus regenerative medicine

AI Caplan - Journal of cellular physiology, 2007 - Wiley Online Library
Adult mesenchymal stem cells (MSCs) can be isolated from bone marrow or marrow
aspirates and because they are culture‐dish adherent, they can be expanded in culture …

Mesenchymal stem cells: time to change the name!

AI Caplan - Stem cells translational medicine, 2017 - academic.oup.com
Mesenchymal stem cells (MSCs) were officially named more than 25 years ago to represent
a class of cells from human and mammalian bone marrow and periosteum that could be …

Multilineage cells from human adipose tissue: implications for cell-based therapies

PA Zuk, MIN Zhu, H Mizuno, J Huang, JW Futrell… - Tissue …, 2001 - liebertpub.com
Future cell-based therapies such as tissue engineering will benefit from a source of
autologous pluripotent stem cells. For mesodermal tissue engineering, one such source of …

Multilineage potential of adult human mesenchymal stem cells

MF Pittenger, AM Mackay, SC Beck, RK Jaiswal… - science, 1999 - science.org
Human mesenchymal stem cells are thought to be multipotent cells, which are present in
adult marrow, that can replicate as undifferentiated cells and that have the potential to …

Human adipose tissue is a source of multipotent stem cells

PA Zuk, M Zhu, P Ashjian, DA De Ugarte… - Molecular biology of …, 2002 - molbiolcell.org
Much of the work conducted on adult stem cells has focused on mesenchymal stem cells
(MSCs) found within the bone marrow stroma. Adipose tissue, like bone marrow, is derived …

Mesenchymal stem cells

AI Caplan - Journal of orthopaedic research, 1991 - Wiley Online Library
Bone and cartilage formation in the embryo and repair and turnover in the adult involve the
progeny of a small number of cells called mesenchymal stem cells. These cells divide, and …

Human mesenchymal stem cells modulate allogeneic immune cell responses

S Aggarwal, MF Pittenger - Blood, 2005 - ashpublications.org
Mesenchymal stem cells (MSCs) are multipotent cells found in several adult tissues.
Transplanted allogeneic MSCs can be detected in recipients at extended time points …

Osteogenic differentiation of purified, culture‐expanded human mesenchymal stem cells in vitro

N Jaiswal, SE Haynesworth, AI Caplan… - Journal of cellular …, 1997 - Wiley Online Library
Human bone marrow contains a population of cells capable of differentiating along multiple
mesenchymal cell lineages. Recently, techniques for the purification and culture‐expansion …

[HTML][HTML] Mechanisms involved in the therapeutic properties of mesenchymal stem cells

L da Silva Meirelles, AM Fontes, DT Covas… - Cytokine & growth factor …, 2009 - Elsevier
Mesenchymal stem cells (MSCs) have been described as being able to give rise to several
quite different mesenchymal cell phenotypes. However, the ability to differentiate is not the …