Regulated cell death (RCD) relies on activation and recruitment of pore-forming proteins
(PFPs) that function as executioners of specific cell death pathways: apoptosis regulator …

Most metastatic cancers remain incurable due to the emergence of apoptosis-resistant
clones, fuelled by intratumour heterogeneity and tumour evolution. To improve treatment …

Necroptosis is a form of regulated cell death that has been implicated in multiple diseases.
TNF-induced necroptosis is regulated by necrosomes, complexes consisting of RIPK1 …

Cell death, particularly that of tubule epithelial cells, contributes critically to the
pathophysiology of kidney disease. A body of evidence accumulated over the past 15 years …

Functional amyloids are a rapidly expanding class of fibrillar protein structures, with a core
cross-β scaffold, where novel and advantageous biological function is generated by the …

Abstract Background & Aims Necroptosis is a highly inflammatory mode of cell death that
has been implicated in causing hepatic injury including steatohepatitis/nonalcoholic …

Necroptosis is a regulated caspase-independent form of necrotic cell death that results in an
inflammatory phenotype. This process contributes profoundly to the pathophysiology of …

Mixed Lineage Kinase domain-Like pseudokinase (MLKL) is implicated in a broad range of
diseases due to its role as the ultimate effector of necroptosis and has therefore emerged as …

The past decade has seen the emergence of the necroptosis programmed cell death
pathway as an important contributor to the pathophysiology of myriad diseases. The receptor …

Inborn errors of TLR3-dependent type I IFN immunity in cortical neurons underlie forebrain
herpes simplex virus-1 (HSV-1) encephalitis (HSE) due to uncontrolled viral growth and …