The relevance of bioinformatics applications in the discovery of vaccine candidates and potential drugs for COVID-19 treatment

OS Chukwudozie, VC Duru… - … and Biology Insights, 2021‏ - journals.sagepub.com
The application of bioinformatics to vaccine research and drug discovery has never been so
essential in the fight against infectious diseases. The greatest combat of the 21st century …

Reverse engineering protection: A comprehensive survey of reverse vaccinology-based vaccines targeting viral pathogens

S Ponne, R Kumar, SM Vanmathi, RSN Brilhante… - Vaccine, 2024‏ - Elsevier
Vaccines have significantly reduced the impact of numerous deadly viral infections.
However, there is an increasing need to expedite vaccine development in light of the …

In silico analysis of epitope-based vaccine candidate against tuberculosis using reverse vaccinology

S Bibi, I Ullah, B Zhu, M Adnan, R Liaqat, WB Kong… - Scientific reports, 2021‏ - nature.com
Tuberculosis (TB) kills more individuals in the world than any other disease, and a threat
made direr by the coverage of drug-resistant strains of Mycobacterium tuberculosis (Mtb) …

Immunoinformatics design of a novel epitope-based vaccine candidate against dengue virus

AO Fadaka, NRS Sibuyi, DR Martin, M Goboza… - Scientific reports, 2021‏ - nature.com
Dengue poses a global health threat, which will persist without therapeutic intervention.
Immunity induced by exposure to one serotype does not confer long-term protection against …

Designing a novel multi‑epitope vaccine against Ebola virus using reverse vaccinology approach

M Alizadeh, H Amini-Khoei, S Tahmasebian… - Scientific reports, 2022‏ - nature.com
Ebola virus (EBOV) is a dangerous zoonotic infectious disease. To date, more than 25 EBOV
outbreaks have been documented, the majority of which have occurred in Central Africa …

Immunoinformatics-guided designing of epitope-based subunit vaccines against the SARS Coronavirus-2 (SARS-CoV-2)

B Sarkar, MA Ullah, FT Johora, MA Taniya, Y Araf - Immunobiology, 2020‏ - Elsevier
Abstract SARS Coronavirus-2 (SARS-CoV-2) pandemic has become a global issue which
has raised the concern of scientific community to design and discover a counter-measure …

Immunoinformatics approach to design novel subunit vaccine against the Epstein-Barr virus

AT Moin, RB Patil, T Tabassum, Y Araf… - Microbiology …, 2022‏ - journals.asm.org
Epstein-Barr virus (EBV) is a lymphotropic virus responsible for numerous epithelial and
lymphoid cell malignancies, including gastric carcinoma, Hodgkin's lymphoma …

In-silico designing of epitope-based vaccine against the seven banded grouper nervous necrosis virus affecting fish species

A Joshi, DC Pathak, MA Mannan, V Kaushik - Network Modeling Analysis …, 2021‏ - Springer
Neural necrosis virus (NNV) of family Nodaviridae affect wide range of fish species with viral
encephalopathy and retinopathy causing mass mortality up to 100%. Currently there is no …

In-silico design of a multivalent epitope-based vaccine against Candida auris

N Akhtar, A Joshi, V Kaushik, M Kumar… - Microbial …, 2021‏ - Elsevier
Candida auris is a rapidly emerging human pathogenic fungus with a high mortality rate.
Recent report suggests that the new clinical isolates are showing resistance to the major …

Identification of Putative Vaccine and Drug Targets against the Methicillin-Resistant Staphylococcus aureus by Reverse Vaccinology and Subtractive Genomics …

RS Naorem, BD Pangabam, SS Bora, G Goswami… - Molecules, 2022‏ - mdpi.com
Methicillin-resistant Staphylococcus aureus (MRSA) is an opportunistic pathogen and
responsible for causing life-threatening infections. The emergence of hypervirulent and …