Indole-containing natural products 2019–2022: isolations, reappraisals, syntheses, and biological activities
Indole alkaloids represent a large subset of natural products, with more than 4100 known
compounds. The majority of these alkaloids are biologically active, with some exhibiting …
compounds. The majority of these alkaloids are biologically active, with some exhibiting …
Mining the biodiversity of plants: a revolution in the making
Only a small fraction of the immense diversity of plant metabolism has been explored for the
production of new medicines and other products important to human well-being. The …
production of new medicines and other products important to human well-being. The …
Total synthesis of the Daphniphyllum alkaloid daphenylline
Z Lu, Y Li, J Deng, A Li - Nature chemistry, 2013 - nature.com
The Daphniphyllum alkaloids are a large class of natural products isolated from a genus of
evergreen plants widely used in Chinese herbal medicine. They display a remarkable range …
evergreen plants widely used in Chinese herbal medicine. They display a remarkable range …
Solution of the multistep pathway for assembly of corynanthean, strychnos, iboga, and aspidosperma monoterpenoid indole alkaloids from 19E-geissoschizine
Monoterpenoid indole alkaloids (MIAs) possess a diversity of alkaloid skeletons whose
biosynthesis is poorly understood. A bioinformatic search of candidate genes, combined …
biosynthesis is poorly understood. A bioinformatic search of candidate genes, combined …
Total synthesis of natural products using gold catalysis
Gold catalysis is an extremely enthusiastic field of investigation in the catalysis area. The
development of alternative, highly inventive, precompetitive techniques based on gold …
development of alternative, highly inventive, precompetitive techniques based on gold …
Organocatalytic cascade aldimine condensation/[1, 6]-hydride transfer/Mannich-type cyclization: sustainable access to indole-2, 3-fused diazocanes
LX Wang, B Qiu, XD An, PZ Dong, RB Liu, J **ao - Green Chemistry, 2021 - pubs.rsc.org
An unprecedented organocatalytic cascade aldimine condensation/[1, 6]-hydride
transfer/Mannich-type cyclization of indole-2-carbaldehydes with o-aminoanilines was …
transfer/Mannich-type cyclization of indole-2-carbaldehydes with o-aminoanilines was …
Decatungstate‐Photocatalyzed Dearomative Hydroacylation of Indoles: Direct Synthesis of 2‐Acylindolines
T Varlet, D Bouchet, E Van Elslande… - … –A European Journal, 2022 - Wiley Online Library
We report herein a convenient and scalable dearomative hydroacylation reaction of indoles.
Employing readily available aldehydes as the acyl source and TBADT as an inexpensive …
Employing readily available aldehydes as the acyl source and TBADT as an inexpensive …
Antiinflammatory Medicinal Plants from the Ugandan Greater Mpigi Region Act as Potent Inhibitors in the COX-2/PGH2 Pathway
Our study investigates 16 medicinal plants via assessment of inhibition of proinflammatory
enzymes such as cyclooxygenases (COX). The plants are used by traditional healers in the …
enzymes such as cyclooxygenases (COX). The plants are used by traditional healers in the …
[HTML][HTML] Atypical opioid receptors: unconventional biology and therapeutic opportunities
Endogenous opioid peptides and prescription opioid drugs modulate pain, anxiety and
stress by activating four opioid receptors, namely μ (mu, MOP), δ (delta, DOP), κ (kappa …
stress by activating four opioid receptors, namely μ (mu, MOP), δ (delta, DOP), κ (kappa …
An interrupted Heyns rearrangement approach for the regioselective synthesis of acylindoles
An efficient and general method for the synthesis of 2-and 3-acylindoles has been achieved
with high regioselectivity from o-acylanilines and α-hydroxycarbonyl or its equivalent. The …
with high regioselectivity from o-acylanilines and α-hydroxycarbonyl or its equivalent. The …