Preeclampsia is one of the “great obstetrical syndromes” in which multiple and sometimes
overlap** pathologic processes activate a common pathway consisting of endothelial cell …

Preeclampsia, one of the most enigmatic complications of pregnancy, is considered a
pregnancy-specific disorder caused by the placenta and cured only by delivery. This article …

Physiological transformation with remodeling of the uteroplacental spiral arteries is key to a
successful placentation and normal placental function. It is an intricate process that involves …

The role of the maternal immune system in reproductive success in humans remains
controversial. Here we focus on the events that occur in the maternal decidua during the first …

Natural killer (NK) cells are present in large populations at the maternal-fetal interface during
early pregnancy. However, the role of NK cells in fetal growth is unclear. Here, we have …

Our understanding of development and function of natural killer (NK) cells has progressed
significantly in recent years. However, exactly how uterine NK (uNK) cells develop and …

BACKGROUND Recurrent miscarriage and pre-eclampsia are common reproductive
disorders, but their causes are often unknown. Recent evidence has provided new insight …

Innate lymphoid cells (ILCs) are the most abundant immune cells in the uterine mucosa both
before and during pregnancy. Circumstantial evidence suggests they play important roles in …

During early pregnancy, decidual innate lymphoid cells (dILCs) interact with surrounding
maternal cells and invading fetal extravillous trophoblasts (EVT). Here, using mass …

Several decades of research have convincingly shown that classical human leukocyte
antigen (HLA) loci bear signatures of natural selection. Despite this conclusion, many …