Neurodegenerative diseases are the most common cause of dementia. Although their
underlying molecular pathologies have been identified, there is substantial heterogeneity in …

Structure–function relationships are a fundamental principle of many naturally occurring
systems. However, network neuroscience research suggests that there is an imperfect link …

Neurotransmitter receptors support the propagation of signals in the human brain. How
receptor systems are situated within macro-scale neuroanatomy and how they shape …

The mechanisms underlying phenotypic heterogeneity in autism spectrum disorder (ASD)
are not well understood. Using a large neuroimaging dataset, we identified three latent …

Gene expression fundamentally shapes the structural and functional architecture of the
human brain. Open-access transcriptomic datasets like the Allen Human Brain Atlas provide …

Functional magnetic resonance imaging (fMRI) enables non-invasive access to the awake,
behaving human brain. By tracking whole-brain signals across a diverse range of cognitive …

Patients with major depressive disorder (MDD) exhibit concurrent deficits in both sensory
and higher-order cognitive processing. Connectome studies have suggested a principal …

The brain is a network of interleaved neural circuits. In modern connectomics, brain
connectivity is typically encoded as a network of nodes and edges, abstracting away the rich …

Numerous brain disorders demonstrate structural brain abnormalities, which are thought to
arise from molecular perturbations or connectome miswiring. The unique and shared …

A central goal in systems neuroscience is the parcellation of the cerebral cortex into discrete
neurobiological “atoms”. Resting-state functional magnetic resonance imaging (rs-fMRI) …