Promising biomarkers of radiation-induced lung injury: a review

X Liu, C Shao, J Fu - Biomedicines, 2021 - mdpi.com
Radiation-induced lung injury (RILI) is one of the main dose-limiting side effects in patients
with thoracic cancer during radiotherapy. No reliable predictors or accurate risk models are …

Cone-beam-CT guided adaptive radiotherapy for locally advanced non-small cell lung cancer enables quality assurance and superior sparing of healthy lung

P Hoegen, C Lang, S Akbaba, P Häring… - Frontiers in …, 2020 - frontiersin.org
Purpose To evaluate the potential of cone-beam-CT (CB-CT) guided adaptive radiotherapy
(ART) for locally advanced non-small cell lung cancer (NSCLC) for sparing of surrounding …

Measuring indirect radiation-induced perfusion change in fed vasculature using dynamic contrast CT

AE Wuschner, MJ Flakus, EM Wallat… - Journal of personalized …, 2022 - mdpi.com
Recent functional lung imaging studies have presented evidence of an “indirect effect” on
perfusion damage, where regions that are unirradiated or lowly irradiated but that are …

CT-derived vessel segmentation for analysis of post-radiation therapy changes in vasculature and perfusion

AE Wuschner, MJ Flakus, EM Wallat… - Frontiers in …, 2022 - frontiersin.org
Vessel segmentation in the lung is an ongoing challenge. While many methods have been
able to successfully identify vessels in normal, healthy, lungs, these methods struggle in the …

SPECT V/Q in lung cancer radiotherapy planning

EM Eslick, MJ Stevens, DL Bailey - Seminars in Nuclear Medicine, 2019 - Elsevier
Curative-intent lung cancer radiation therapy either alone (RT) or combined with immuno-
chemotherapy is associated with potential risk of serious radiation-induced lung injury. This …

Synthetic pulmonary perfusion images from 4DCT for functional avoidance using deep learning

EM Porter, NK Myziuk, TJ Quinn… - Physics in Medicine …, 2021 - iopscience.iop.org
Purpose. To develop and evaluate the performance of a deep learning model to generate
synthetic pulmonary perfusion images from clinical 4DCT images for patients undergoing …

Comparison of regional lung perfusion response on longitudinal MAA SPECT/CT in lung cancer patients treated with and without functional tissue-avoidance radiation …

HMT Thomas, J Zeng, HJ Lee, Jr… - The British Journal of …, 2019 - academic.oup.com
Objective: The effect of functional lung avoidance planning on radiation dose-dependent
changes in regional lung perfusion is unknown. We characterized dose-perfusion response …

Validation of CT-based ventilation and perfusion biomarkers with histopathology confirms radiation-induced pulmonary changes in a porcine model

MJ Flakus, AE Wuschner, EM Wallat, M Graham… - Scientific reports, 2023 - nature.com
Imaging biomarkers can assess disease progression or prognoses and are valuable tools to
help guide interventions. Particularly in lung imaging, biomarkers present an opportunity to …

Patient-reported lung symptoms and quality of life before and after radiation therapy for non-small cell lung cancer: correlation with radiation pneumonitis and …

KP Farr, AA Khalil, C Grau - Acta Oncologica, 2019 - Taylor & Francis
Radiation-induced toxicity, particularly radiation pneumonitis (RP), negatively affects
patientsL quality of life (QOL) and survival after definitive thoracic radiation therapy (RT)[1 …

Imaging for response assessment in radiation oncology: current and emerging techniques

S Stieb, K Kiser, L van Dijk… - Hematology …, 2020 - hemonc.theclinics.com
Computed tomography (CT), magnetic resonance imaging (MRI), and positron emission
tomography (PET) play a major role in the assessment of tumor response. Moreover, these …