Brain insulin resistance and hippocampal plasticity: mechanisms and biomarkers of cognitive decline

M Spinelli, S Fusco, C Grassi - Frontiers in neuroscience, 2019 - frontiersin.org
In the last decade, much attention has been devoted to the effects of nutrient-related signals
on brain development and cognitive functions. A turning point was the discovery that brain …

Nutrition and adult neurogenesis in the hippocampus: Does what you eat help you remember?

S Melgar-Locatelli, M de Ceglia… - Frontiers in …, 2023 - frontiersin.org
Neurogenesis is a complex process by which neural progenitor cells (NPCs)/neural stem
cells (NSCs) proliferate and differentiate into new neurons and other brain cells. In …

Chemotherapy, cognitive impairment and hippocampal toxicity

J Dietrich, M Prust, J Kaiser - Neuroscience, 2015 - Elsevier
Cancer therapies can be associated with significant central nervous system (CNS) toxicity.
While radiation-induced brain damage has been long recognized both in pediatric and adult …

Hippocampal dosimetry correlates with the change in neurocognitive function after hippocampal sparing during whole brain radiotherapy: a prospective study

PF Tsai, CC Yang, CC Chuang, TY Huang, YM Wu… - Radiation …, 2015 - Springer
Background Whole brain radiotherapy (WBRT) has been the treatment of choice for patients
with brain metastases. However, change/decline of neurocognitive functions (NCFs) …

[HTML][HTML] Loss of CDKL5 impairs survival and dendritic growth of newborn neurons by altering AKT/GSK-3β signaling

C Fuchs, S Trazzi, R Torricella, R Viggiano… - Neurobiology of …, 2014 - Elsevier
Mutations in the X-linked cyclin-dependent kinase-like 5 (CDKL5) gene have been identified
in a neurodevelopmental disorder characterized by early-onset intractable seizures, severe …

The addicted brain craves new neurons: putative role for adult-born progenitors in promoting recovery

CD Mandyam, GF Koob - Trends in neurosciences, 2012 - cell.com
Addiction is a chronic relapsing disorder associated with compulsive drug taking, drug
seeking and a loss of control in limiting intake, reflected in three stages of a recurrent cycle …

Persistent loss of hippocampal neurogenesis and increased cell death following adolescent, but not adult, chronic ethanol exposure

MA Broadwater, W Liu, FT Crews… - Developmental …, 2014 - karger.com
Although adolescence is a common age to initiate alcohol consumption, the long-term
consequences of exposure to alcohol at this time of considerable brain maturation are …

A place for the hippocampus in the cocaine addiction circuit: Potential roles for adult hippocampal neurogenesis

E Castilla-Ortega, A Serrano, E Blanco, P Araos… - Neuroscience & …, 2016 - Elsevier
Cocaine addiction is a chronic brain disease in which the drug seeking habits and profound
cognitive, emotional and motivational alterations emerge from drug-induced …

Interplay between pro-inflammatory cytokines and growth factors in depressive illnesses

MC Audet, H Anisman - Frontiers in cellular neuroscience, 2013 - frontiersin.org
The development of depressive disorders had long been attributed to monoamine
variations, and pharmacological treatment strategies likewise focused on methods of …

Adult hippocampal neurogenesis modulates fear learning through associative and nonassociative mechanisms

D Seo, MA Carillo, SCH Lim, KF Tanaka… - Journal of …, 2015 - Soc Neuroscience
Adult hippocampal neurogenesis is believed to support hippocampus-dependent learning
and emotional regulation. These putative functions of adult neurogenesis have typically …