Variations and similarities in our individual genomes are part of our history, our heritage,
and our identity. Some human genomic variants are associated with common traits such as …

Determining the catalytic residues in an enzyme is critical to our understanding the
relationship between protein sequence, structure, function, and enhancing our ability to …

Determining the catalytic site of enzymes is a great help for understanding the relationship
between protein sequence, structure, and function, which provides the basis and targets for …

The recent accumulation of experimentally determined protein 3D structures combined with
our ability to computationally model structure from amino acid sequence has resulted in an …

Elucidating the precise molecular events altered by disease-causing genetic variants
represents a major challenge in translational bioinformatics. To this end, many studies have …

Abstract Background Missense pharmacogenomic (PGx) variants refer to amino acid
substitutions that potentially affect the pharmacokinetic (PK) or pharmacodynamic (PD) …

Advances in DNA sequencing technologies have made it possible to rapidly, accurately and
affordably sequence entire individual human genomes. As impressive as this ability seems …

The geometric structures of proteins are vital to the understanding of biochemical
interactions. However, there is much yet to be understood about the spatial arrangements of …

A variety of algorithms have been developed for catalytic residue prediction based on either
feature-or template-based methodology. However, no studies have systematically compared …

Graph kernels for learning and inference on sparse graphs have been widely studied.
However, the problem of designing robust kernel functions that can effectively compare …