Recent advances in methamphetamine neurotoxicity mechanisms and its molecular pathophysiology

S Yu, L Zhu, Q Shen, X Bai, X Di - Behavioural neurology, 2015 - Wiley Online Library
Methamphetamine (METH) is a sympathomimetic amine that belongs to phenethylamine
and amphetamine class of psychoactive drugs, which are widely abused for their stimulant …

Into rather unexplored terrain—Transcellular transport across the blood–brain barrier

M De Bock, V Van Haver, RE Vandenbroucke… - Glia, 2016 - Wiley Online Library
Efficient neuronal signaling in the central nervous system strictly depends on a well‐
balanced microenvironment around glial cells, synapses, and axons. Unique features of the …

Drugs of abuse and blood-brain barrier endothelial dysfunction: A focus on the role of oxidative stress

RK Sajja, S Rahman, L Cucullo - Journal of Cerebral Blood …, 2016 - journals.sagepub.com
Psychostimulants and nicotine are the most widely abused drugs with a detrimental impact
on public health globally. While the long-term neurobehavioral deficits and synaptic …

[HTML][HTML] CCL4 induces inflammatory signalling and barrier disruption in the neurovascular endothelium

C Estevao, CE Bowers, D Luo, M Sarker… - Brain, behavior, & …, 2021 - Elsevier
Background During neuroinflammation many chemokines alter the function of the blood-
brain barrier (BBB) that regulates the entry of macromolecules and immune cells into the …

Methamphetamine dysregulation of the central nervous system and peripheral immunity

DR Miller, M Bu, A Gopinath, LR Martinez… - The journal of …, 2021 - Elsevier
Methamphetamine (METH) is a potent psychostimulant that increases extracellular
monoamines, such as dopamine and norepinephrine, and affects multiple tissue and cell …

[HTML][HTML] Methamphetamine induces systemic inflammation and anxiety: the role of the gut–immune–brain axis

M Davidson, M Mayer, A Habib, N Rashidi… - International journal of …, 2022 - mdpi.com
Methamphetamine (METH) is a highly addictive drug abused by millions of users worldwide,
thus becoming a global health concern with limited management options. The inefficiency of …

The role of actin-binding proteins in the control of endothelial barrier integrity

A García-Ponce, AF Citalán-Madrid… - Thrombosis and …, 2015 - thieme-connect.com
The endothelial barrier of the vasculature is of utmost importance for separating the blood
stream from underlying tissues. This barrier is formed by tight and adherens junctions (TJ …

A comprehensive review of the neonatal Fc receptor and its application in drug delivery

JP Martins, PJ Kennedy, HA Santos, C Barrias… - Pharmacology & …, 2016 - Elsevier
Advances in the understanding of neonatal Fc receptor (FcRn) biology and function have
demonstrated that this receptor, primarily identified for the transfer of passive immunity from …

Impact of methamphetamine on infection and immunity

SA Salamanca, EE Sorrentino, JD Nosanchuk… - Frontiers in …, 2015 - frontiersin.org
The prevalence of methamphetamine (METH) use is estimated at~ 35 million people
worldwide, with over 10 million users in the United States. METH use elicits a myriad of …

The impact of substance abuse on HIV-mediated neuropathogenesis in the current ART era

V Chilunda, TM Calderon, P Martinez-Aguado… - Brain research, 2019 - Elsevier
Approximately 37 million people worldwide are infected with human immunodeficiency virus
(HIV). One highly significant complication of HIV infection is the development of HIV …